Allosteric site

Allosteric site
In biochemistry, allosteric regulation is the regulation of an enzyme or other protein by binding an effector molecule at the protein's allosteric site .

allosteric site
(al-oh-steer-ik)
A specific receptor site on an enzyme molecule remote from the active site.

[edit] Allosteric sites as drug targets
Allosteric sites may represent a novel drug target.There are a number of advantages in using allosteric modulators as preferred therapeutic agents over classic orthosteric ligands.

The binding of an inhibitor to an allosteric site is usually temporary. Poisons are inhibitors that bind irreversibly. For example, penicillin inhibits an enzyme needed by bacteria to build the cell wall.

and irreversible (i.e.antagonist binds covalently to the agonist binding site, and no amount of agonist can overcome the inhibition). Other types of antagonism are non-competitive antagonism where the antagonist binds to an allosteric site on the ...

See also: Site, Molecule, Enzyme, Trans, Protein