AP endonuclease
Apurinic/apyrimidinic (AP) endonuclease is an enzyme that is involved in the DNA base excision repair pathway (BER). Its main role in the repair of damaged or mismatched nucleotides in DNA is to create a nick in the...
AP endonuclease
An endonuclease which recognizes an AP site and cuts the defective strand on the 5' side of the missing base.
AP site
A molecule of single-stranded or double-stranded DNA missing a purine or pyrimidine base.
DNA polymerase I then "reads" the fragments, removes the RNA using its flap endonuclease domain, and replaces the RNA nucleotides with DNA nucleotides (this is necessary because RNA and DNA use slightly different kinds of nucleotides).
 See also: Enzyme, Nucleotide, Nuclease, DNA, Endonuclease
  
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