Avidin
A protein that binds biotin with a very high affinity. Used for the detection of biotinylated probes.
Avidin
Axon
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AVIDIN - A glycoprotein which binds to biotin with very high affinity (Kd = 10-15).
BACK MUTATION - Reverse the effect of a point or frame-shift mutation that had altered a gene; thus it restores the wild-type phenotype (see REVERTANT).
Biotin has an extraordinarily high affinity for streptavidin with a reported dissociation constant of ~10-15. This very strong binding affinity has made the biotin-streptavidin system very attractive for a multitude of in vitro labeling applications.
Important in fatty acid biosynthesis and catabolism and has found widespread use as a covalent label for macromolecules which may then be detected by high affinity binding of labelled avidin or streptavidin. Essential growth factor for many cells.
labelling a probe with congugated biotin, whose high affinity for avidin or anti-biotin antibody is exploited in immunoassays ...
For example, ribonuclease inhibitor binds to ribonuclease A with a roughly 20 fM dissociation constant. Other proteins have evolved to bind specifically to unusual moieties on another protein, e.g., biotin groups (avidin), ...
 See also: DNA, Enzyme, Biology, Genome, Biotin
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