Meiotic Breakpoints. Two groups reported algorithms concerned with defining meiotic breakpoints in the CEPH families.
Breakpoint
Refers to sites of breakage when chromosomes break (and recombine).
Related Terms:
Chromosome
The term was proposed by Waldeyer (1888) for the individual threads within a cell nucleus (gk. chroma, colour; soma, body).
the breakpoint may occur within a gene creating a hybrid gene. This may be transcribed and translated into a protein with an N-terminal of one normal cell protein coupled to the C-terminal of another.
This allows chromosomes of otherwise equal size to be differentiated as well as to elucidate the breakpoints and constituent chromosomes involved in chromosome translocations.
Unequal crossing over A crossover in which the chromosomal segments exchanged are not equally sized because the breakpoint has occurred at a different place on each homologue.
gene conversions and deletions in the MHC-linked 21-hydroxylase gene (CYP21), gene conversions within the MHC class II genes in mice and humans, many oncogene translocations (BCL2 for example) are attributed to chi-like sequences at the breakpoint ...
 See also: Chromosome, Genome, Human, Chromosomes, DNA
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