Breakpoint

Breakpoint Refers to sites of breakage when chromosomes break (and recombine). Related Terms: Chromosome ... Full article ...

Meiotic Breakpoints. Two groups reported algorithms concerned with defining meiotic breakpoints in the CEPH families.

the breakpoint may occur within a gene creating a hybrid gene. This may be transcribed and translated into a protein with an N-terminal of one normal cell protein coupled to the C-terminal of another.

This allows chromosomes of otherwise equal size to be differentiated as well as to elucidate the breakpoints and constituent chromosomes involved in chromosome translocations.

Unequal crossing over A crossover in which the chromosomal segments exchanged are not equally sized because the breakpoint has occurred at a different place on each homologue.

gene conversions and deletions in the MHC-linked 21-hydroxylase gene (CYP21), gene conversions within the MHC class II genes in mice and humans, many oncogene translocations (BCL2 for example) are attributed to chi-like sequences at the breakpoint ...

See also: Genome, Chromosome, Human, Mapping, Hybrid