Checkpoint One of several points in the cell cycle where the cycle can pause if there is a problem such as incomplete DNA synthesis or damaged DNA. See cell cycle.
Checkpoints: Quality Control of Meiosis
It shouldn't be surprising that things can go wrong in such a complicated process. However, cells going through meiosis have checkpoints that monitor each pair of homologues for ...
Checkpoint genes are the genes that say stop multiplying, stop your cell cycle, if something is not quite in order. One of the early accidents in the development of cancer cells is that they lose checkpoint genes.
Earlier cell cycle checkpoints such a post-restriction point check between G1 phase and S phase similarly involve proteasomal degradation of cyclin A, whose ubiquitination is promoted by the anaphase promoting complex (APC), an E3 ubiquitin ligase.
Most notably we have identified a null allele of the repair/checkpoint gene mei-41 and demonstrated intermediate levels of repair competency and checkpoint function in heterozygotes for this mutation.
As in both G1 and G2, there is a Checkpoint in the middle of mitosis (Metaphase Checkpoint) that ensures the cell is ready to complete cell division. Actual stages of mitosis can be viewed at Animal Cell Mitosis.
Rapidly dividing cancer cells that have lost checkpoint systems insuring genome fidelity can develop resistance to specific anti-cancer drugs.
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 See also: Cells, Cell, Trans, Cell cycle, Protein
  
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