The restoration of activity or partial activity (complementation) to an enzyme made of identical subunits (polypeptides encoded by one gene) in a heterozygote of two different mutant alleles of that gene.
Complementation
As we saw above, rapid lysis (r) mutants were found that mapped to three different regions of the T4 genome: rI, rII, and rIII.
This meant that ...
Complementation The ability of two different mutations to produce a wild type phenotype in a double heterozygote. This gives a very strong indication that they do not both affect the same gene (cases of intragenic complementation are very rare).
Complementation
The ability of a gene to produce a functional gene product which compensates for the mutant phenotype caused by a mutation in another gene. Typically, the complementing gene produces a gene product (e.g.
Complementation: The production of a wildtype phenotype when two recessive mutations from different genes are brought together.
Complementation
The process by which two recessive mutants can supply each other's deficiency, such that a heterokaryon or diploid derived fron them and having the trans (repulsion) configuration is phenotypically normal (wild-type) or nearly so.
Complementation test
A mating test to determine whether two different recessive mutations (a1;a2) on opposite chromosomes (trans, a1+/+a2) of a diploid or partial diploid will not complement (ie have a mutant phenotype) each other; ...
Complementation
- Process by which genes on different DNA molecules interact. Usually a protein product is involved, as this is a diffusible molecule that can exert its effect away from the DNA itself.
(1) In vivo complementation for cloning mouse mutations. We developed an in vivo library of the 550 kb region to which the mouse recessive neurological mutation vibrator had been localized by meiotic mapping.
Synthetic lethality or unlinked non-complementation - two mutations fail to complement and yet do not map to the same locus.
AD, AR, XD, XR, CD: Patterns of Mendelian inheritance
Allelic and locus heterogeneity (complementation tests)
Variable expressivity and incomplete penetrance
Quantitative Genetics ...
 See also: Complement, Gene, Chromosome, Sequence, Genome
  
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