The mechanism is based on the prion hypothesis, which posits that self-perpetuating changes in the conformation of single protein, PrP, underlie the severe neurodegeneration associated with the transmissible spongiform enchephalopathies in mammals.
Conformation
Pyran and furan, after which the pyranose and furanose rings forms of monosaccharides are named.
Beta Conformation
consists of pairs of chains lying side-by-side and
stabilized by hydrogen bonds between the carbonyl oxygen atom on one chain and the -NH group on the adjacent chain.
CONFORMATIONAL EPITOPE - An epitope which is dependent upon folding of a protein; amino acid residues present in the antibody binding site are often located at sites in the primary sequence of the protein which are at some distance from each other.
Random-coil conformation The disordered, unfolded structure of a denatured macromolecule; ...
Single stranded conformational polymorphism (SSCP)
A method for distinguishing between similar sized DNA fragments according to the mobility of the single-stranded DNA under polyacrylamide gel electrophoresis.
The inhibition of PFK by ATP is unusual, since ATP is also a substrate in the reaction catalyzed by PFK; the biologically active form of the enzyme is a tetramer that exists in two possible conformations, ...
Karush, Quiocho, and Wright, furthermore, all have pointed out that conformational disorder mediates binding diversity because a flexible chain can adopt different conformations to fit with different ligands.
[Normally], when a hormone binds to a receptor, you get these really neat conformational changes that then cause gene expression to ensue. Most androgen insensitivity cases involve mutations where the hormone would be binding.
in cells in which Ptc activity is absent or abrogated by Hh signaling, a process that seems to involve the redistribution of a hyperphosphorylated form of the protein to the cell surface (Denef, 2000) and may also be accompanied by a conformational ...
Conditions that alter the conformation of a protein which regulates expression of other genes.
(Science: molecular biology) conformation or shape that two linear strands of dna assume when bonded together and become twisted into a helix.
For proteins, a process in which a protein unravels and loses its native conformation, thereby becoming biologically inactive. For DNA, the separation of the two strands of the double helix.
SSCP
See single stranded conformational polymorphism
Related Terms:
Single stranded conformational polymorphism (SSCP) ...
Denature the process whereby a protein looses its native conformation
(de = from‚ down‚ out; nata = born‚ produced)
Dendrite the "incoming" end of a neuron
(dendro = tree) ...
D. the allosteric enzyme is locked in an inactive conformation
E. all substrate has been converted to product ...
an enzyme is a globular protein with an active site which bind to substrate molecules and helps to catalyse a reaction by holding melecules in the correct spatial conformation for the reaction to take place .
The substrate molecule normally does not fit exactly in the active site. This induces a change in the enzymes conformation (shape) to make a closer fit.
carrier proteins - membrane transport protein that binds to a solute and transports it across the membrane by undergoing a series of conformational changes ...
The motor proteins involved in organelle transport operate by altering their three-dimensional conformation using adenosine triphosphate (ATP) as fuel to move back and forth along a microtubule.
 See also: Protein, Trans, Proteins, Molecule, Cell
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