Dosage compensation is a genetic regulatory mechanism which operates to equalize the phenotypic expression of characteristics determined by genes on the X chromosome so that they are equally expressed in the human XY male and the XX female.
dosage compensation
the cellular mechanisms that compensate for the activity of genes, which because of their location on the X chromosome, exist in two doses in females and one in males ...
Dosage compensation The imbalance caused by having two copies of the X chromosome in females compared to only one copy in males is countered (in humans) by X inactivation or (in Drosophila) by reducing the relative level of activity of X linked ...
Dosage compensation: The phenomenon in women, who have two copies of genes on the X chromosome, of having the same level of the products of those genes as males (who have a single X chromosome).
Dosage Compensation
Although females have twice as many X-linked genes, the amount of protein produced by these genes is the same in females as it is in males.
...
Dosage compensation
Reference
Carrel L, Willard HF. X-inactivation profile reveals extensive variability in X-linked gene expression in females.. Nature 2005;434:400-404. PMID 15772666.
Lyon MF.
of New York Health Science Center), covers a wide spectrum of topics, including a comprehensive introduction; an anatomy of the genome; the molecular biology of heterochromatin, kinetochores, and centromeres; meiotic chromosomes; dosage compensation ...
X-inactivation -- the repression of one of the two X-chromosomes in the somatic cells of females as a method of dosage compensation; at an early embryonic stage in the normal female, one of the two X-chromosomes undergoes inactivation, ...
 See also: Human, Chromosome, Chromosomes, DNA, Sex
|
