Downstream (or 3' to) is in the direction of transcription (or translation) whereas upstream (5' to) is in the direction from which the polymerase (or ribosome) has come.
Downstream
A sequence located after a particular site relative to the direction of transcription and translation (i.e. located to the 3' side of a particular site). For example, the lacZ structural gene is located downstream of the lac promoter.
Downstream Genes have an orientation which is defined by their direction of transcription (5' to 3'). Downstream means further in the direction of transcription of a gene and even possibly beyond its end.(Opposite is upstream.) ...
Downstream. The region extending in a 3' direction from a gene.
dscDNA. See double-stranded complementary DNA.
Duplex DNA. Double-stranded DNA.
Downstream: The direction which RNA polymerase moves during transcription (5' to 3') and ribosomes moves during translation.
Downstream
The region extending in the 3' direction from a gene.
Related Terms:
Gene
The term coined by Johannsen (1909) for the fundamental physical and functional unit of heredity.
DOWNSTREAM - Identifies sequences proceeding farther in the direction of expression; for example, the coding region is downstream from the initiation codon, toward the 3' end of an mRNA molecule.
Downstream: See "Upstream/Downstream".
E. coli: A common Gram-negative bacterium useful for cloning experiments. Present in human intestinal tract. Hundreds of strains of E. coli exist. One strain, K-12, has been completely sequenced.
New types of "downstream" public databases are also being developed for information such as gene expression patterns. Although the idea of a single, integrated database sounds appealing, this is probably not feasible.
Downstream (← links)
Nitracrine (← links)
Nuclear rna (← links)
Gene product (← links)
Chromatin (← links)
Fish analysis (← links)
Host cell (← links)
Plant rnase (← links)
Viruses (← links)
Yeast rnase (← links) ...
And that's a great question and because we really don't know what SRY is doing downstream we can't answer that question yet. Everybody wants to say it activates another gene, but it could easily repress a gene.
Water that id dammed up no longer freely flows, placing wetland habitats downstream from the dam at risk.
Phosphatidyl 4-phosphate 5-kinase is stimulated by PA in vitro and this enzyme is the downstream effector of a significant subset of PLD signalling pathways.
It is performed with gene trap vectors whose principal element is a gene trapping cassette consisting of a promoterless reporter gene and/or selectable genetic marker flanked by an upstream 3' splice site (splice acceptor; SA) and a downstream ...
Enhancers differ from promoters in being farther away from, and either upstream (5') or downstream (3') of, the gene they influence.
A mutation that alters the normal triplet reading frame so that codons downstream from the mutation are out of register and not read properly.
Related Terms:
Mutation ...
Intergenic region include sequences upstream and downstream of experimentally determined 5' and 3' UTRs.
oxygen sag Oxygen decline downstream from a pollution source that introduces materials with high biological oxygen demands.
oxyhemoglobin Compound formed when oxygen combines with hemoglobin.
Web ChangBioscience.com
UTR See Untranslated region (UTR)
Ubiquitin
Untranscribed Region
Untranslated region (UTR)
Upstream/Downstream ...
in a gene that influences the gene's expression by increasing or decreasing its rate of RNA synthesis (via effects on binding and transcription of the basal transcription apparatus including RNA Polymerase); can be located upstream (5'), downstream ...
If a transposon inserts itself within another gene, it can prevent the gene from expressing itself. Sometimes the transposon carries a gene which can become activated if it becomes inserted downstream from an active promoter.
Pribnow box A promoter component of prokaryotic genes that has the consensus sequence 5'- TATAAA-3' located 10 base pairs downstream from the transcription start site.
when splicing mRNA, U1 binds to 5' GU and U2 binds to branch site (A), then U4,U5,U6 complex comes, and U6 replaces the U1 position. U1 and U4 leaves, then U2 and U6 associate to form the lariat intron, and U5 helps bring the upstream and downstream ...
And so the change in DNA sequence may actually be in the disease gene itself that they're looking for, but more frequently it's just what it says: It's a marker of it, which could be upstream or downstream, ...
 See also: Trans, Gene, Protein, Sequence, DNA
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