Euploidy is the state of a cell or organism having an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes.
, or the euploid number is the normal number of chromosomes within a cell for a species, for example the euploid number of chromosomes in a human cell is 46.
1 Haploid ...
Cells that have extra chromosomes or chromosomes missing are aneuploid. Two types of aneuploidy are discussed below.
In primates (in contrast to sheep, cattle, and mice), the process of removing the resident nucleus causes molecules associated with the centrosome to be lost as well.
Aneuploidy having an abnormal number of chromosomes
(aneu = without; ploid = set of chromosomes) ...
an Variation in chromosome number involving one or a small number of chromosomes; commonly involves the gain or loss of a single chromosome.
The condition of a cell or organism that has one or more complete sets of chromosomes.
The term was proposed by Waldeyer (1888) for the individual threads within a cell nucleus (gk. chroma, colour; soma, body).
Change in chromosome number from one generation to the next in which there is an addition or deletion of a complete set of chromosomes in the progeny; the most common type is polyploidy.
Aneuploidy -- state of having variant chromosome number (too many or too few). (i.e. Down syndrome, Turner syndrome).
Bond U, Neal C, Donnelly D, James TC: An and copy number breakpoints in the genome of lager yeasts mapped by microarray hybridisation. ...
Aneuploidy — The state of having an abnormal number of chromosomes. A euploid human karyotype has 46 chromosomes (figure 1).
In haploids, in X-linked genes in fly or human males or in dipoloids as a result of an or deletion.
The term coined by Johannsen (1909) for the fundamental physical and functional unit of heredity.
If the organism survives, aneuploidy typically leads to a distinct phenotype.
Aneuploidy can also occur during failures of the mitotic spindle.
Results in an
Usually embryo lethal
Trisomy 21, exception leading to Downs syndrome
Turner syndrome: monosomy X
Klinefelter syndrome: XXY ...
Non disjunction and changes in number (pre and post zygotic); polyploidy, aneuploidy, spontaneous abortions (SABs), advanced maternal age (AMA)
Changes in structure ...
chromosomal mutations /krome-ə-ZOME-əl/ Changes in the karyotype; may result from a translocation, an inversion, an, or polyploidy. MORE INFORMATION ...
See also: Chromosome, Ploidy, Aneuploid, Aneuploidy, Chromosomes