Gene amplification

Gene Amplification
Gene amplification is an increase in the number of copies of a gene sequence. Cancer cells sometimes produce multiple copies of genes in response to signals from other cells or their environment.

Gene amplification
Multiple copies of a single gene within a cell.
Gene conversion
An genetic event that produces abnormal segregations by non-reciprocal recombination.

gene amplification
The selective synthesis of DNA, which results in multiple copies of a single gene, thereby enhancing expression.
gene cloning ...

Gene amplification. The presence of multiple genes. Amplification is one mechanism through which proto-oncogenes are activated in malignant cells.

Gene amplification Repeated copying of a piece of DNA; a characteristic of tumor cells.
See also: gene, oncogene ...

Gene amplification
- The increase, within a cell, of the number of copies of a given gene.
Gene bank ...

Modification of DNA Gene Amplification
In Drosophila (fruit flies), the chorion (eggshell) gene is copied many times in certain cells of the oviduct. These cells make large quantities of the protein needed to surround the egg.

(See Dominant gene, Fusion gene, Gene amplification, Gene expression, Gene flow, Gene pool, Gene splicing, Gene translocation, Recessive gene, Regulatory gene.) Gene amplification. The presence of multiple genes.

Gene amplification -- any process by which specific DNA sequences are replicated disproportionately greater than their representation in the parent molecules; during development, some genes become amplified in specific tissues.

Genome-wide analysis of DNA copy-number changes using cDNA microarrays "Gene amplifications and deletions frequently contribute to tumorigenesis.

Expression of cathepsin B is regulated at many different levels, from gene amplification, use of alternative promoters, increased transcription and alternative splicing, to increased stability and translatability of transcripts.

The probable answer: gene amplification. Having multiple copies of genes permits a high level of gene expression; that is, abundant transcription and translation to produce the gene products.

Other genes undergo a process called gene amplification where there may be two copies of the gene present in normal cells and 20 or 50 or a hundred copies of the gene, often a growth promoting gene, present in cancer cells, ...

As in various types of gene mutation such as trinucleotide repeat amplification or myc gene amplification - naturally occuring aberrations which have greatly increased the copy number of a triplet repeat or of a whole gene respectively in vivo.

See also: Amplification, Gene, DNA, Trans, Cells