Gene conversion is an event in DNA genetic recombination, which occurs at high frequencies during meiotic division but which also occurs in somatic cells.
In asci of Ascomycete fungi a 4:4 ratio of alleles is expected after meiosis, yet 6:2 and 5:3 ratios are sometimes observed. A model of recombination, produced by Holliday, suggests that gene conversion may be explained by repair of heteroduplex DNA.
Gene conversion
An genetic event that produces abnormal segregations by non-reciprocal recombination.
Gene Conversion
If the sequence used as a template for repairing a gene by homologous recombination differs slightly from the gene needing repair; that is, is an allele, the repaired gene will acquire the donor sequence.
GENE CONVERSION - The alteration of all or part of a gene by a homologous donor DNA that is itself not altered in the process.
GENOME - The complete set of genetic information defining a particular animal, plant, organism or virus.
One is gene conversion. This is a phenomena by which one stretch of DNA "erases" another stretch and copies itself in it's place. The mechanism is well known, but I don't have time to explain it. Any molecular bio text will have that info.
Whitehouse and Hastings (1965) have suggested that if gene conversion is due to the correction of mispairing of bases in DNA, it may give rise to reciprocal as well ac nonreciprocal recombination.
Related Terms:
Allele ...
Recombination may come about through random orientation of non-homologous chromosome pairs on the meiotic spindles, from crossing-over between homologous chromosomes, from gene conversion, or by other means. See homologous recombination.
MHC class I transmembrane domain length variation, frequent gene conversions and deletions in the MHC-linked 21-hydroxylase gene (CYP21), gene conversions within the MHC class II genes in mice and humans, ...
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Rozen, S., H. Skaletsky, J. D. Marszalek, P. J. Minx, H. S. Cordum, R. H. Waterson, R. K. Wilson, and D. C. Page. 2003. Abundant gene conversion between arms of palindromes in human and ape Y chromosomes. Nature 423:873-76.
97 percent identical. The extensive use of gene conversion appears to play a role in the ability of the Y chromosome to edit out genetic mistakes and maintain the integrity of the relatively few genes it carries.
 See also: Conversion, Chromosome, Recombination, Chromosomes, Gene
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