germ line
the cell line that produces gametes
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...
Germ Line
A germ line is the sex cells (eggs and sperm) that are used by sexually reproducing organisms to pass on genes from generation to generation.
Germ line gene therapy An experimental process of inserting genes into germ cells or fertilized eggs to cause a genetic change that can be passed on to offspring. May be used to alleviate effects associated with a genetic disease.
Germ line
The continuation of a set of genetic information from one generation to the next.
See also: inherit
Germ line gene therapy ...
[edit] Germ line gene therapy
In the case of germ line gene therapy, germ cells, i.e., sperms or eggs, are modified by the introduction of functional genes, which are ordinarily integrated into their genomes.
Germ line mosaicism
Presence of 2 or more cell lines that differ in genetic makeup among gametes (germ cells); implies risk of transmission of mutations present in the gonads to offspring. Cf. mosaicism
Related Terms:
Gamete ...
Germ line
see gamete.
Related Terms:
Gamete
Mature male or female reproductive cell (sperm or ovum) with a haploid set of chromosomes (23 for humans).
Germ cell (germ line) gene therapy. The repair or re- placement of a defective gene within the gamete-forming tissues, which produces a heritable change in an organism's genetic constitution.
GMO. Genetically modified organism.
In some cases, the first mutation is already present in a germ line cell (egg or sperm); thus, all the cells in the individual inherit it. Because the mutation is recessive, the trait is not expressed.
Gametogenesis is the process of forming gametes (by definition haploid, n) from diploid cells of the germ line.
Multicellular organisms would need the directed mutation to occur in it's germ line cells for it to be evolutionarily interesting; and germ line cells are the least likely to be exposed to the stress.
An experimentally produced organism in which DNA has been artificially introduced and incorporated into the organism's germ line, usually by injecting the foreign DNA into the nucleus of a fertilized embryo. [Talking Glossary]
Translation ...
TRANSGENIC - An animal (usually a mouse) or plant into which a foreign gene has been introduced in the germ line. An example: transgenic mice expressing the human receptor for poliovirus are susceptible to human polioviruses.
Embryonic stem (ES) cells: Cell lines derived from early embryos that have the potential to differentiate into all types of somatic cells as well as to form germ line cells, and hence whole animals, when injected into early embryos.
 See also: Cell, Human, Cells, Organ, DNA
  
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