hemoglobinopathies
abnormal hemoglobins caused by changes in the amino acid composition of the protein
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...
hemoglobin A red pigment in red blood cells that can bind with oxygen and is largely responsible for the blood's oxygen-carrying capacity. Hemoglobin is composed of four polypeptide chains, two alpha (a) and two beta (b) chains.
hemoglobin -- protein complex found in the blood of most chordates and the roots of certain legumes. It binds oxgen molecules, and in chordates serves as the means by which the oxygen is supplied to the cells of the body.
hemoglobin
(hee-moh-gloh-bin) [Gk. haima, blood + L. globus, a ball]
An iron-containing protein in red blood cells that reversibly binds oxygen.
hemophilia ...
Hemoglobin respiratory pigment in the blood‚ which contains a porphyrin ring with iron in the center
(heme = blood; glob = ball) ...
Hemoglobinopathy A genetic disorder resulting from any number of mutations that produce insufficient amounts of normal hemoglobin or normal amounts of defective hemoglobin chains.
[edit] Hemoglobin
A bleeding finger: blood has a distinctive red color.
Hemoglobin is a soluble protein - found in the cytoplasm of red blood cells as single molecules - which bind oxygen and carry it to the tissues.
Hemoglobin - To access a tutorial on normal and sickle cell hemoglobin structures, click on the large "Hemoglobin" link on the Web page created by Dr. Eric Martz at the Department of Microbiology, University of Massachusetts.
Hemoglobinopathies, blood types, enzyme deficiencies, lysosomal storage diseases, peroxisomal diseases, CF, NF1, OI, DMD/BMD, De Lange, TSD, PKU, FH, galactosemia, Marfan, achondroplasia, FGFR's, skeletal disorders, hemochromatosis, etc.
Hemoglobin transports NO at the same time it carries oxygen [Link to discussion]. When it unloads oxygen in the tissues, it also unloads NO.
hemoglobin An iron-containing respiratory pigment occurring in vertebrate red blood cells and in blood plasma of many invertebrates; a compound of an iron porphyrin heme and globin proteins.
hemoglobinuria Bloody urine.
abnormal hemoglobin Hemoglobin molecule with a different shape due to an altered amino acid sequence (ultimately caused by an altered DNA base sequence), such as in the inherited disease sickle-cell anemia.
Structure of hemoglobin. The protein subunits are in red and blue, and the iron-containing heme groups in green. From PDB 1GZX.
[edit] Minerals and cofactors
Further information: Physiology, bioinorganic chemistry, cofactor and iron metabolism ...
Erythrocytes -- the hemoglobin-containing cell found in the blood of vertebrates. Euchromatin -- the chromatin that shows the staining behavior characteristic of the majority of the chromosomal complement.
Now, the mutation does not really affect the ability of beta-globin to participate with alpha-globin and make hemoglobin, and it doesn't affect the ability to carry oxygen.
Subsequently the hemoglobin is dissolved out, and the envelope can barely be distinguished as a faint circular outline.
Sickle-cell anemia is an abnormality of hemoglobin, the molecule that carries oxygen in our blood. Hemoglobin is contained within red blood cells.
Bohr effect. When blood pH decreases, the ability of hemoglobin to bind to oxygen decreases. An adaptation to release oxygen in the oxygen starved tissues in capillaries where respiratory carbon dioxide lowers blood pH ...
Red cells get their red color from iron-rich hemoglobin which is responsible for transporting oxygen throughout the body. These cells got THEIR red color from Photoshop(R). See animated red cells in capillaries in "OUCH!... Anatomy of a Splinter".
One of the ways that lead makes people sick is by interfering with the protein that helps make hemoglobin. The result is an anemic like condition where your blood can't carry enough oxygen to keep you healthy.
erythrocyte
A red blood cell; contains hemoglobin, which functions in transporting oxygen in the circulatory system. These are the most common cell type of the blood.
Proteins have many different functions: structure(collagen); movement (actin and myosin); catalysis (enzymes); transport (hemoglobin); regulation of cellular processes (insulin); ...
The Iron of hemoglobin was generated in the moment when the atomic nuclei of a star fused to form heavier elements; for example Iron.
A protein has several functions. It may serve as a structural material (e.g. keratin), as enzymes, as transporters (e.g. hemoglobin), as antibodies, or as regulators of gene expression.
erythropoiesis - red blood cell (erythrocyte) development, including pluripotential stem cell division, restriction of potential and differentiation into a mature red blood cell containing hemoglobin.
 See also: Trans, Cells, Protein, Organ, Human
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