A model that explains both crossing over and gene conversion by assuming the production of a short stretch of heteroduplex DNA (formed from both parental DNAs) in the vicinity of a chiasma.
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Heteroduplex DNA
A double-stranded DNA molecule formed by annealing complementary (or partially complementary) single-stranded DNA from two different sources.
Heteroduplex. A double-stranded DNA molecule or DNA-RNA hybrid, where each strand is of a different origin.
Heteroduplex analysis
The study of the mobilities of heteroduplex DNA under polyacrilamide gel electrophoresis. The reduced mobility of heteroduplex DNA compared with homoduplex DNA is proportional to the degree of divergence of the sequences.
By forming heteroduplexes between sequenced and test molecules, deletions, substitutions, and perhaps even point mutations, can be imaged and precisely located by AFM.
So long as the total number of nucleotides in each strand and the complementarity (A-T, C-G) is preserved, this "heteroduplex" region (which may extend for hundreds of base pairs) will only rarely have genetic consequences.
A method for separating DNA fragments according to their mobilities under increasingly heat-denaturing conditions. See also DGGE, SSCP and heteroduplex analysis.
 See also: DNA, Sequence, Molecule, Genome, Lysis
  
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