Heteroduplex analysis
The study of the mobilities of heteroduplex DNA under polyacrilamide gel electrophoresis. The reduced mobility of heteroduplex DNA compared with homoduplex DNA is proportional to the degree of divergence of the sequences.
The mutations are identified by high-throughput heteroduplex analysis followed by DNA sequencing of PCR products from this large bank. Stocks of mice carrying the specific gene mutation can be reconstituted from the frozen gametes.
A method for separating DNA fragments according to their mobilities under increasingly heat-denaturing conditions. See also DGGE, SSCP and heteroduplex analysis.
 See also: Lysis, Heteroduplex, DNA, Gel, Electrophoresis
  
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