Integrase Inhibitors
A drug that inhibits the HIV-1 integrase has safely slowed disease progression in experimental animals (monkeys) and is undergoing clinical trials in humans.
Inhibiting Coreceptor Binding ...
It uses reverse transcriptase, which I talked about-which allows the RNA to become DNA; it uses "integrase.
A segment of DNA on the mobile element matches exactly with a segment of DNA on the target, allowing enzymes called integrases to insert the rest of the mobile element into the target. Integrases are a special type of Recombinases.
One of the problems of gene therapy using retroviruses is that the integrase enzyme can insert the genetic material of the virus in any arbitrary position in the genome of the host.
The drugs interfer with HIV replication at multiple steps as indicated above (integrase inhibitors in developmental stages only).
When viral RNA is translated into a polypeptide sequence, that sequence is assembled in a long chain that includes several individual proteins (reverse transcriptase, protease, integrase).
Within their characteristic long terminal repeats (LTRs), some retrotransposons encode retroviral-like proteins (e.g., gag, pol) for reverse transcriptase and integrase.
recombination requires little sequence homology between the two DNA molecules. The best understood example is the integration of lambda into the E. coli chromosome by recombination between attP and attB catalyzed by the lambda integrase protein.
 See also: Trans, DNA, Protein, Proteins, Cells
  
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