Knock-Out (KO)
Deleting or mutating a gene in the genome such that the gene is not functional.
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KNOCK-OUT - The excision or inactivation of a gene within an intact organism or even animal (e.g., "knock-out mice"), usually carried out by a method involving homologous recombination.
Knock-out experiment: A technique for deleting, mutating or otherwise inactivating a gene in a mouse.
To create a "knock-out" pig, scientists must inactivate the genes that cause the human immune system to reject an implanted pig organ.
Genetic interactions (epistasis) can often confound simple interpretations of such "knock-out" studies.
Molecular biology is the study of molecular underpinnings of the process of replication, transcription and translation of the genetic material.
transposons encode a transposase and are capable of transposing on their own. Transposition of non-autonomous elements requires trans-activation from the autonomous element. Insertion of a transposable element into a gene may create a knock-out, ...
 See also: DNA, Molecular biology, Bacteria, Cells, Gene
  
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