Linkage disequilibrium The occurrence, on the same chromosome, of some combinations of alleles of closely linked genes more often than would be predicted by chance.
Linkage disequilibrium Where alleles occur together more often than can be accounted for by chance. Indicates that the two alleles are physically close on the DNA strand.
See also: Mendelian inheritance ...
Linkage disequilibrium
When the observed frequencies of haplotypes in a population does not agree with haplotype frequencies predicted by multiplying together the frequency of individual genetic markers in each haplotype.
Linkage disequilibrium is a measure of association between alleles of two different genes.
Whether a selective sweep has occurred or not can be investigated by measuring linkage disequilibrium, or whether a given haplotype is overrepresented in the population.
Allelic association: see linkage disequilibrium.
Allelic exclusion: Expression of only one of the two homologous alleles at a locus in the case of heterozygosity.
Because of this tendency of a particular set of SNPs to remain together, called linkage disequilibrium, one can use one probe for a single SNP (called a "tag SNP") to search for the presence of the complete haplotype.
The procedure: ...
A set of closely linked genetic markers present on one chromosome which tend to be inherited together (not easily separable by recombination). Some haplotypes may be in linkage disequilibrium.
This is what we call linkage disequilibrium, and the HapMap defined that across the whole genome for the first time in a way that is extremely valuable for trying to understand the relationship between variation and disease.
fission in prokaryotes, mitosis or meiosis in eukaryotes), and hence the greater the probability that they will be inherited together. Cf. recombination, complete linkage, partial linkage, non-linkage, linkage equilibrium, linkage disequilibrium.
This methodology has several applications, such as amplifying certain haplotypes (when certain alleles at 2 or more SNPs occur together on the same chromosome [Linkage Disequilibrium]) or detection of recombinant chromosomes and the study of meiotic ...
 See also: Linkage, Equilibrium, Chromosome, DNA, Gene
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