MHC Database Combines Map and Sequence Data
Investigators at the U.K.
TCR/MHC-peptide pair
On the T cell, the T-cell receptor for antigen (TCR) bound to
a Major Histocompatibility Complex molecule on the Antigen-Presenting Cell (APC).
[edit] MHC evolution and allelic diversity
MHC gene families are found in essentially all vertebrates, though the gene composition and genomic arrangement vary widely.
MHC See major histocompatibility complex.
micelle Lipid aggregates with a surface coat of bile salts. A stage in the digestion of lipids in the small intestine.
Class I MHC proteins Membrane proteins that tightly bind proteolytic fragments of cellular proteins and present them to the scrutiny of T cells.
Once activated by a MHC-antigen complex, TC cells release the protein perforin, which forms pores in the target cell's plasma membrane; this causes ions and water to flow into the target cell, making it expand and eventually lyse.
15-30 3 Roles for asparagine endopeptidase in class II MHC-restricted antigen processing C. Watts, D. Mazzeo, M.A. West, S.P. Matthews, D. Keane, G. Hamilton, L.V. Persson, J.M. Lawson, B. Manoury and C.X. Moss.........
One case of this phenomenon occurs at loci at the major histocompatibility complex (MHC) wherein some human alleles are much more closely related to some chimpanzee alleles than they are to other human alleles (Fig. 7).
MHC class I transmembrane domain length variation, frequent gene conversions and deletions in the MHC-linked 21-hydroxylase gene (CYP21), gene conversions within the MHC class II genes in mice and humans, ...
major histocompatibility complex (MHC)
A large set of cell surface antigens encoded by a family of genes. Foreign MHC markers trigger T-cell responses that may lead to the rejection of transplanted tissues and organs.
Malpighian tubule ...
When the macrophage eats bacteria, proteins (antigens) from the bacteria are broken down into short peptide chains and those peptides are then "displayed" on the macrophage surface attached to special molecules called MHC II (for Major ...
Human HLA genes (equivalent to MHC genes in mice) have many alleles, and no two individuals have identical alleles at all gene loci. Which of the following are consequences of this genetic diversity?
A. ...
two of these may be critical to the epitope's specificity and the avidity of the antibody-antigen reaction. B-cell epitopes may be either linear or conformational in nature. T-cell epitopes represent the small, processed peptides which bind to MHC ...
 See also: Human, Protein, Cells, Cell, Trans
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