mutagen
any substance that induces mutations
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...
Mutagen
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Mutagen
In biology, a mutagen (Latin, literally origin of change) is an agent that changes the genetic information (usually DNA) of an organism and thus increases the number of mutations above the natural background level.
Mutagen
A mutagen is a chemical or physical phenomenon, such as ionizing radiation, that promotes errors in DNA replication. Exposure to a mutagen can produce DNA mutations that cause or contribute to diseases such as cancer.
The production of either random or specific mutations in a piece of cloned DNA. Typically, the DNA will then be reintroduced into a cell or an organism to assess the results of the mutagenesis.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
Mutagen
A chemical or physical agent that increases the frequency of mutation, usually by directly damaging the DNA.
Mutagenesis
The formation of mutations.
mutagen
(myoot-uh-jen) [L. mutare, to change + genus, source or origin]
A chemical or physical agent that interacts with DNA and causes a mutation.
mutagenesis ...
Mutagen A physical or chemical factor which increases the mutation rate.
Mutant phenotype A phenotype which is different from the wild type phenotype and which is caused by the possession of one or more mutant alleles.
Mutagen. Any agent or process that can cause mutations. See Mutation.
Mutation. An alteration in DNA structure or sequence of a gene. (See Point mutation.)
Mutualism. See Symbiosis.
Mutagenesis
When a chemical or physical agent is used to cause permanent genetic alterations.
Source : Human Genome Project Information
Nuchal translucency test ...
Mutagen
An agent that causes a permanent genetic change in a cell. Does not include changes occurring during normal genetic recombination.
Mutagenicity ...
Mutagenicity The capacity of a chemical or physical agent to cause permanent genetic alterations.
See also: somatic cell genetic mutation
Mutation Any heritable change in DNA sequence.
See also: polymorphism ...
Mutagen Perturbs to the base sequence of DNA and causes a mutation; often chemicals but can also be energy sources such as ultraviolet light.
mutagen Any substance capable of causing a mutation.
mutagens Agents, such as chemicals or radiation, that damage or alter genetic material (DNA) in cells.
It has mutagenic, carcinogenic, and teratogenic activity. It is formed by the enzymatic hydroxylation of aflatoxin b1 by aflatoxin b1 4-hydroxylase, a cytochrome p-450-dependent enzyme.
Pharmacological action: carcinogens, mutagens, teratogens.
an active mutagen in the Ames test;
causes an increase in the incidence of tumors in rats (that are forced to swallow water containing levels of MX far higher than those ever found in water supplies).
Directed mutagenesis
Two new papers examining the phenomena of directed mutations have recently appeared in the literature. I'll quickly review these experiments in the next post.
While these mutagenic chemicals resided in his bladder, they attacked genes of cells lining the walls of the bladder. They attacked those genes randomly and willy-nilly creating mutations here, there and everywhere.
SITE-DIRECTED MUTAGENESIS - The introduction of a mutation, usually a point mutation or an insertion, into a particular location in a cloned DNA fragment.
fast neutrons Mutagen that typically produces small deletions. Cloning of mutated genes is facilitated by PCR and subtractive hybridization methods to detect deletions.
Pauling first described the a-helix nearly 50 years ago, yet new features of its structure continue to be discovered, using peptide model systems, sitedirected mutagenesis, advances in theory, ...
They are not mutagens. Mutagens act randomly on all DNA and do not produce one specific genotype. Children who have been exposed to teratogens in utero will not pass their defect on to their children.
Chromosomal DNA accumulates mutations at a predictable rate as a result of errors in replication and environmental mutagens, which are not corrected by DNA repair systems.
Genetic modifications to enzymes through protein engineering techniques such as site-directed mutagenesis and DNA shuffling have allowed scientists to enhance the catalytic properties of certain enzymes under specific industrial conditions such as ...
A key feature of insertional mutagenesis for the identification of plasmids containing recombinant DNA is:
A.
the production of nutritional auxotrophs.
Since mutations can be induced (by radiation or chemicals), Morgan and his coworkers were able to cause new alleles to form by subjecting fruit flies to mutagens (agents of mutation, or mutation generators).
carcinogens - a substance that causes the initiation of tumor formation. Frequently a mutagen
connective tissues B a primary tissue; form and function vary extensively. Functions include support, storage, and protection.
Left unchecked, they have the potential to cause mutagenesis and carcinogenesis.
DNA that has been created artificially. Basic recombinant DNA techniques include restriction digestion, ligation, site-directed mutagenesis, PCR, and cloning in plasmid or other vectors.
Other Resources
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Most carcinogens (cancer-generating factors) are also mutagens (mutation-generating factors). Oncogenes are genes resembling normal genes but in which something has gone wrong, resulting in a cancer.
 See also: DNA, Trans, Organ, Human, Cell
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