Recent advances suggest that whole microbial cells could be imaged by electron tomography to "molecular" resolution, sufficient to locate and identify large macromolecular complexes in their native state within their cellular contexts.
[edit] Stability of native states
The most typical conformation of a protein in its cellular environment is generally referred to as the native state or native conformation.
Most often researchers use them to study the static "native states" of macromolecules. But variations on these methods are also used to watch nascent or denatured molecules assume or reassume their native states (see e.g. protein folding).
 See also: Protein, Proteins, Sequence, Biology, Acids
  
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