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Nonsense Mutation

Biology Non-disjunctionNontarget organism

nonsense mutation
a mutation that changes a codon from one that specifies an amino acid into one that does not; there are three such nonsense codons
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...

 


Nonsense Mutation
A nonsense mutation is the substitution of a single base pair that leads to the appearance of a stop codon where previously there was a codon specifying an amino acid.

Nonsense mutations
With a nonsense mutation, the new nucleotide changes a codon that specified an amino acid to one of the STOP codons (TAA, TAG, or TGA).

Nonsense mutation
A mutation which replaces a codon for an amino acid with a codon for chain termination (UAG, UAA, or UGA).

nonsense mutation
A mutation that changes an amino acid codon to one of the three stop codons, resulting in a shorter and usually nonfunctional protein.
noradrenaline ...

Nonsense mutation A point mutation which alters a codon so that instead of coding for an amino-acid it codes for a translation stop signal.

[edit] Nonsense mutation
Main article: Nonsense mutation
A nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed mRNA, and possibly a truncated, ...

Nonsense mutation
Mutation that changes a codon or an amino acid to a termination or stop codon and leads to premature termination of translation.
Related Terms:
Mutation ...

Silent, Missense, and Nonsense Mutations
Three kinds of point mutations can occur. A mutation that results in an amino acid substitution is called a missense mutation.

Humans have 347 functional odor receptor genes; the other genes have nonsense mutations. This number was determined by analyzing the genome in the Human Genome Project; the number may vary among ethnic groups, and does vary among individuals.

A mutation that affects the transcription or translation of part of the gene or operon downstream of the mutant site. For example, nonsense mutations, frameshift mutations, and insertion sequence(IS)-induced mutations.

Nonsense mutation -- a mutation in which a codon is changed to a stop codon, resulting in a truncated protein product.

See also: Sense, Trans, Mutation, DNA, Codon

Biology Non-disjunctionNontarget organism

 
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