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Nuclein

Biology  Nucleic acids  Nucleoid

Nuclein. The term used by Friedrich Miescher to describe the nuclear material he discovered in 1869, which today is known as DNA.


Later nuclein was resolved into an acidic component, nucleic acid,and a basic component, primarily proteins known as histones.
Eukaryotic cells contain a distinct structure, the nucleus, where nuclein was localized.

Honore B, Baandrup U, Nielsen S, Vorum H: Endonuclein is a cell cycle regulated WD-repeat protein that is up-regulated in adenocarcinoma of the pancreas. ...

He called the compound nuclein. This is today called nucleic acid, the NA in DNA (deoxyribo-nucleic-acid) and RNA (ribo-nucleic-acid).
The DNA Files: The genetic revolution affects us every day: our health, our food, our families.

Nucleic acids were discovered in 1868 by Friedrich Miescher, who called the material 'nuclein' since it was found in the nucleus.[44] It was later discovered that prokaryotic cells, which do not have a nucleus, also contain nucleic acids.

In that timeline "biochmists" in the early 1900's are credited with the discovery that "nuclein" (DNA) is made up of nucleotides which contain a phosphate group, a 5-carbon sugar, and a nitrogen base. Who were these scientists?

Since it came from nuclei, Meischer named this new chemical, nuclein. Subsequently the name was changed to nucleic acid and lastly to deoxyribonucleic acid (DNA). Robert Feulgen, in 1914, discovered that fuchsin dye stained DNA.

His experiments revealed that nuclei contained a chemical that contained nitrogen and phosphorus but no sulfur. He called the chemical nuclein because it came from nuclei. It later became known as nucleic acid.

See also: See also: Protein, Cells, Sequence, Proteins, Trans

Biology  Nucleic acids  Nucleoid

 
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