Permutation
A permanent and heritable change in a gene that does not have phenotypic consequences (does not cause disease) but predisposes to a future mutation.
Related Terms:
Gene ...
Somatic Hypermutation (SHM)
Class Switch Recombination (CSR)
T Cells
Alpha/beta (αβ) T cells
Gamma/delta (γδ) T cells ...
Somatic hypermutation serves to increase the diversity of the antibody pool and impacts the antibody's antigen-binding affinity.
permutations. Hence, imagine augmenting the above strategy so that the matching probes are arranged one after the other with the nondegenerate regions overlapping but offset by k base pairs.
Therefore you can immediately understand that a large number of different proteins with totally different functions can be made from different permutations and combinations of these 20 amino acids strung together into "protein words.
See: operation, permutation.
Transformation can be a synonym for metamorphosis and shapeshifting, as in the stories featured on the Transformation Stories Archive.
2. (Science: mathematics) permutation.
3. The response of the congregation speaking alternately with the minister. Alternation of generation. See generation.
Origin: L. Alternatio: cf. F. Alternation.
As reported in Rao 1998, Volvo has used an evolutionary program called OptiFlex to schedule its million-square-foot factory in Dublin, Virginia, a task that requires handling hundreds of constraints and millions of possible permutations for each ...
The reason is that there are billions and billions of permutations as to how that folding can occur and we don't understand it well enough to be able to say which is the exact one that occurs. Computationally, it's an extremely difficult problem.
There are many molecular mechanisms for antigenic variation, including inversion, recombination between multiple casettes, and hypermutation. Antigenic variation occurs in eukaryotic microbes (e.g. Trypanosomes), bacteria (e.g.
 See also: Mutation, Trans, Protein, Sequence, Genome
  
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