proto-oncogene
A gene that when mutated or otherwise altered becomes an oncogene.
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...
Proto-oncogenes are normal genes that are somehow involved in this process of cell division. Their DNA may contain the code for growth factors or some chemical that needs to be activated in order to stimulate cell division.
Proto-oncogene A gene which may mutate to become an oncogene.
Pseudogene A DNA sequence which resembles a gene but which has been inactivated by mutation so that it cannot produce a functional product.
Proto-oncogene. See oncogene.
Primary cell. A cell or cell line taken directly from a living organism, which is not immortalized.
Proto-oncogene A signal transduction protein that usually regulates cell growth in some fashion; when proto-oncogenes mutated, they become oncogenes and contribute to the development of cancer.
[edit] Proto-oncogene
A proto-oncogene is a normal gene that can become an oncogene due to mutations or increased expression. Proto-oncogenes code for proteins that help to regulate cell growth and differentiation.
Proto-oncogenes and tumor suppressor genes work much like the accelerator and brakes of a car, respectively. The normal speed of a car can be maintained by controlled use of both the accelerator and the brake.
proto-oncogenes (like RAS or a cyclin gene)
tumor-suppressor genes (like p53).
Although tumor-suppressor genes are recessive, mutations in one may be accompanied by a loss of the other allele (called loss-of-heterozygosity).
PROTO-ONCOGENE - A cellular oncogene-like sequence which is thought to play a role in controlling normal cellular growth and differentiation.
Proto-oncogene: A gene present in a normal cell which carries out a normal cellular function, but which can become an oncogene under certain circumstances.
The proto-oncogene product c-Myc can induce cell growth and proliferation.
(See Library.) Cellular oncogene (proto-oncogene). A normal gene that when mutated or improperly expressed contributes to the development of cancer. (See Oncogene.) Centers of origin.
Within every cell in our body is a class of genes known as proto-oncogenes. Proto-oncogenes play important roles in controlling cell division and cell death during our growth and development.
Oncogenes are generally mutated forms of normal cellular genes (proto-oncogenes). A gene capable, when activated, of transforming a cell.
Proto-oncogene (← links)
Deetjens bodies (← links)
Aneurysmoplasty (← links)
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oncogene Any of a number of genes that are associated with neoplastic growth (cancer). The gene in its benign state, either inactivated or carrying on its normal role, is a proto-oncogene.
oncomiracidium A ciliated larva of a monogenetic trematode.
 See also: Oncogene, Trans, Cells, Cell, Protein
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