Open Reading Frame
An open reading frame is a portion of a DNA molecule that, when translated into amino acids, contains no stop codons.
Open Reading Frame (ORF)
Regions of DNA/RNA sequences that have the potential to code for proteins.
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Start codons in different reading frames generate different polypeptides from the same DNA sequence.
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Reading frame
The sequence of nucleotides which is read as consecutive triplets during translation of mRNA into protein. A sequence of codons that continues without encountering a stop codon is called an open reading frame (ORF).
Reading frame The way in which nucleotides are read in groups of three (codons) to specify the polypeptide coded by a gene.
Reading frame A group of three nonoverlapping nucleotides that is read as a codon during protein synthesis; the reading frame begins with the initiator codon AUG.
Open reading frame. A long DNA sequence that is unin- terrupted by a stop codon and encodes part or all of a protein. (See Reading frame.) ...
Open reading frame (ORF) The sequence of DNA or RNA located between the start-code sequence (initiation codon) and the stop-code sequence (termination codon).
Operon A set of genes transcribed under the control of an operator gene.
[edit] Reading frame of a sequence
Note that a codon is defined by the initial nucleotide from which translation starts.
Reading frame
Register in which translation machinery reads the genetic triplicate code.
Related Terms:
Translation
The process in which the genetic code carried by mRNA directs the synthesis of proteins from amino acids.
READING FRAME - Refers to a polypeptide sequence potentially encoded by a single-stranded mRNA.
Reading frame: When mRNA is translated by the cell, the nucleotides are read three at a time. By starting at different positions, the groupings of three that are produced can be entirely different.
Open reading frame (ORF)
A sequence of DNA following an initiation codon that does not contain a stop codon. Detection of an open reading frame in DNA implies the presence of a gene that codes for a protein.
Related Terms:
DNA sequence ...
Open Reading Frame
A brief description of the concept of an open reading frame (ORF).
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ORF Open reading frame. A continuous sequence of nucleotide triplets (codons) in which each triplet codes for an amino acid.
a shift in the reading frame during translation, caused by the addition or deletion of bases in a DNA molecule
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row
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Exon: The coding sequence of a eukaryotic gene (see also open reading frame).
Exon - intron boundary: Introns end with the dinucleotide ApG [3' splice site / acceptor] and start with the dinucleotide GpT [5' splice site / donor].
Search the genome database for an open reading frame (ORF) that contains that sequence.
Translate that ORF to get the entire amino acid sequence of your protein.
What Does This New Protein Do?
ORF An open reading frame (ORF) corresponds to any nucleotide sequence that can potentially encode a protein.
In the test problems, the GA with multiple reading frames produced significantly better solutions than a standard GA on two out of the four problems and better average solutions on the remaining two.
- A mutation caused by either the insertion or deletion of a number od nucleotide pairs in DNA, the effect of which is a change in the reading frame of codens in an mRNA molecule during the protein synthesis, ...
ORDA NIH Office of Recombinant DNA Activities
ORISE Oak Ridge Inst. for Science and Education
ORF open reading frame
ORNL Oak Ridge National Laboratory
OSU Oregon State University
OTA Office of Technology Assessment ...
Reading frame open (← links)
Rearrangement (← links)
Actomyosin (← links)
Degp protease (← links)
Deficiency protein c (← links)
Sh domains (← links)
Brefeldin a (← links)
Blood albumin (← links)
Ldl (← links) ...
Frame-shift mutations occur when the reading frame of the gene is shifted by addition or deletion of one or more bases. With the exception of mitochondria, all organisms use the same genetic code.
The intron's code must be properly expressible, otherwise a stop codon or a shift in the reading frame will cause the protein to be non-functional.
 See also: Sequence, DNA, Protein, Trans, Gene
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