Cre recombinase, often abbreviated to Cre, is a Type I topoisomerase from P1 bacteriophage that catalyzes site-specific recombination of DNA between loxP sites.
Recombinase
An enzyme that catalyzes genetic recombination.
Recombination
Genetic exchange resulting from a cross-over between two different DNA molecules or different regions of a DNA molecule.
Recombinase An enzyme that catalyzes the exchange of genetic material when two DNA molecules recombine.
Recombinase
Isomerase; enzyme catalyses the processes of DNA recombination, used in recombinant DNA technology.
The process of site-specific DNA recombination is involved in viral integration, excision and chromosomal segregation.
cre-lox recombination DNA constructs that contain either the Cre recombinase gene or the lox target sites for the Cre protein. The lox sites are used to direct the site of recombination when the Cre protein is present.
We have examined the potential for using heterologous lox sites and cre recombinase for this purpose. Five apparently heterologous lox sites (wild type, 511, 2372, 5171 and fas) have been described.
A gene encoding a recombinase — an enzyme that can remove the spacer in the toxin gene thus allowing to be expressed.
A repressor gene whose protein product binds to the promoter of the recombinase thus keeping it inactive.
Method for the introduction of genetic modifications into specific genes by homologous recombination using Cre a site-specific, bacteriophage P1-derived recombinase. The Cre recombinase cuts at the loxP-tagged genes.
Requires the MHC, T-cell receptors (TCR) and immunoglobulins (Ig) as well as enzymes with a recombinase activity (for the rearrangements at TCR and Ig gene loci).
 See also: Gene, Protein, DNA, Cell, Enzyme
  
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