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Silent Mutation

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Silent mutations
Most amino acids are encoded by several different codons. For example, if the third base in the TCT codon for serine is changed to any one of the other three bases, serine will still be encoded.

 


Silent mutation
A mutation which changes the nucleotide sequence but does not cause a detectable change in the phenotype.

Silent mutations are mutations that do not result in a change to the amino acid sequence of a protein.

silent mutation A permanent genetic change, but one that is never expressed by the phenotype.
silica (SiO3) A mineral similar to glass that is the major component of the cell wall, shell, or skeleton of many marine organisms.

First, the base substitution can be a silent mutation where the altered codon corresponds to the same amino acid. Second, the base substitution can be a missense mutation where the altered codon corresponds to a different amino acid.

This is called a synonymous mutation or silent mutation; non-synonymous substitutions do cause a change in the amino acid. About half of all SNPs in genes are non-synonymous and therefore can account for diversity between individuals or populations.

A mutation that produces a functioning protein is called a silent mutation.
Exercise - Understanding DNA, mRNA, tRNA, and protein.
Exercise 1.

Different techniques, however, seem to consistently produce estimates of 1 to 6 point non-silent mutations in coding DNA per individual in humans.

See also: DNA, Mutation, Gene, Sequence, Organ

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