An AP site, also known as an abasic site, is a location in DNA that has neither a purine nor pyrimidine base, usually due to DNA damage.
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The spatial confines of a particular project.
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AP site Apurinic or apyrimidinic site resulting from the loss of a purine or pyrimidine residue from the DNA.
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Chi site
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Binding site
Specific DNA/RNA sequences a protein or protein complex bind. Some examples of protein binding sites are promoters, ribosome entry sites, and replication origins.
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fragile site
a heritable chromosomal point, visible after a specific staining procedure, where breaks may occur spontaneously
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...
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Site-specific recombination
Genetic exchange that occurs between particular, short DNA sequences. Site-specific recombination systems do not require RecA.
Site-directed mutagenesis. The process of introducing spe- cific base-pair mutations into a gene.
Site-specific mutagenesis The use of recombinant DNA technology to create specific deletions, insertions, or substitutions in vitro in a particular gene; ...
Cap site: The initiation site of transcription in a eukaryotic gene.
Donor site see splice donor site.
Dosage compensation The imbalance caused by having two copies of the X chromosome in females compared to only one copy in males is countered (in humans) by X inactivation or (in Drosophila) by reducing the ...
Splice-site mutations
The removal of intron sequences, as pre-mRNA is being processed to form mRNA, must be done with great precision. Nucleotide signals at the splice sites guide the enzymatic machinery.
active site
The specific portion of an enzyme that attaches to the substrate by means of weak chemical bonds.
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poly A site The polyadenylation site defines the place in the gene where addition of a sequence of polyadenylic acid to the 3' end of an RNA after transcription will occur.
Splice site Location in the DNA sequence where RNA removes the noncoding areas to form a continuous gene transcript for translation into a protein.
Site
The position occupied by a mutation within the gene. (Cf. Locus.
Related Terms:
Mutation
The term which De Vries introduced into biological literature for an abrupt change of genotype which is inherited.
Cap site: Two usages: In eukaryotes, the cap site is the position in the gene at which transcription starts, and really should be called the "transcription initiation site".
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sink A site of collection of metabolites, such as sugar; metabolic sinks may exist anywhere in the plant where organic solutes are being transported by the phloem and stored.
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Restriction site
Shortened term for restriction endonuclease recognition sequence.
Related Terms:
Restriction enzyme
A bacterially derived protein that recognizes specific, short nucleotide sequences and cuts DNA at those sites.
Promoter: A site on DNA to which RNA polymerase will bind and initiate transcription.
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leaves The site of photosynthesis; one of the three major organs in plants.
leukocytes White blood cells; primarily engaged in fighting infection.
operator - site on DNA at which repressor protein binds to prevent transcription, e.g. in the lac operon.
organogenesis - creation of specific tissues and bodily organs by cell interaction and rearrangement following gastrulation.
droplets of the analysed stream into different fractions depending on the fluorescence emitted by each droplet.
Flow karyotyping Use of flow cytometry to analyse and/or separate chromosomes on the basis of their DNA content.
Fragile Site A ...
An enzyme-substrate complex forms when the enzyme's active site binds with the substrate like a key fitting a lock.
chiasma The site where the exchange of chromosome segments between homologous chromosomes takes place (crossing-over) (pl.: chiasmata). PICTURE
chitin A polysaccharide contained in fungi; also forms part of the hard outer covering of insects.
Oocyte (oh-oh-SITE) The developing female reproductive cell; an immature egg.
Organ A group of tissues that perform a particular job. Animals have more than a dozen organs, including the heart, brain, eye, liver, and lung.
reservoir. The site where a pest population or quantity of inoculum can survive in the absence of a host crop, and from which a new crop may be invaded.
residue management. Management of rice straw and stubble after harvest.
The exchange of DNA fragments between two DNA molecules or chromatids of paired chromosomes (during crossing over) at the site of identical nucleotide sequences. Homozygote.
The mitochondrial permeability transition (PT) pore, also called the mitochondrial megachannel, is a multiprotein complex formed at the contact site between the mitochondrial inner and outer membranes, exactly the same location at which Bax, ...
PromoterA short base sequence which is positioned close to the 5" end of a gene and acts as a recognition and binding site for the RNA polymerase complex prior to transcription of the gene.
RAPD Random amplification of polymorphic DNA.
The junction of the skin of the thigh with that on the front of the abdomen is marked by a well-defined furrow which indicates the site of the inguinal ligament; the furrow presents a general convexity downward, but its medial half, ...
As with eukaryotes, the membrane controls the permeability of the cell and is the major site of energy metabolism.
Genetic modifications to enzymes through protein engineering techniques such as site-directed mutagenesis and DNA shuffling have allowed scientists to enhance the catalytic properties of certain enzymes under specific industrial conditions such as ...
A ribosome is a cellular particle made of RNA and protein that serves as the site for protein synthesis in the cell.
- A nuclear organelle of eukaryotes, associated with the chromosomal site of genes coding for rRNA
Nucleosome
- The basic structural unit of eukaryotic chromosome, composed of an octomer and DNA ...
nucleus -- Membrane-bound organelle which contains the DNA in the form of chromosomes. It is the site of DNA replication, and the site of RNA synthesis.
Recruitment. The residue of those larvae that have: (1) dispersed; (2) settled at the adult site; (3) made some final movements toward the adult habitat; (4) metamorphosed successfully, and (5) survived to be detected by the observer ...
Restriction enzyme cutting site: A specific sequence of DNA at which a particular restriction enzyme cuts the DN A.
Promoter: A regulatory element that specifies the start site of transcription.
Pronuclear injection: The use of a fine needle to inject DNA into the nucleus of an unfertilized egg.
This page is part of the Developmental Biology ONLINE! web site. Special thanks to Tara McParland and Suzanne Gray for the preparation of this glossary.
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Department of Zoology, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
The upper edge of the blastopore produced by invagination during gastrula formation in amphibian embryos; the site toward which surface cells of the gastrula converge and migrate inward along the roof of the blastocoel in the process of involution.
sampling - examination of representative parts of an area or site of interest in a specified and usually repeatable manner with the intent to gain understanding of the whole Entomology 402 (2009) - Glossary - p. 13 ...
Epididymis coiled tubules‚ found within the scrotum‚ that store sperm and are the site of their final maturation
(epi = upon‚ over; didym = testes) ...
restriction nucleases - one of a large number of nucleases that can cleave a DNA molecule at any site where a specific short sequence of nucleotides occurs ...
centromere - constriction in an unreplicated chromosome which results in two regions or arms ; serves as an attachment site for sister chromatids and spindle fibers .
Also called Ammon's horn. Circonvolution of rhinencephalon visible as a swelling in the floor of the lateral ventricle of the brain. Prime site of Negri bodies in the big pyramidal neuronal cells ...
With each step, the motor molecule releases one portion of the microtubule and grips a second site farther long the filament. Motor proteins, which are grouped into several distinct classes, attach to organelles through specialized receptors.
 See also: Trans, Cells, Human, DNA, Organ
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