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Biology Sister ChromatidsSite-specific recombination

Site-specific recombination
Genetic exchange that occurs between particular, short DNA sequences. Site-specific recombination systems do not require RecA.
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site
The spatial confines of a particular project.
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AP site Apurinic or apyrimidinic site resulting from the loss of a purine or pyrimidine residue from the DNA.
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Binding site
Specific DNA/RNA sequences a protein or protein complex bind. Some examples of protein binding sites are promoters, ribosome entry sites, and replication origins.
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fragile site
a heritable chromosomal point, visible after a specific staining procedure, where breaks may occur spontaneously
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...

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A chi site or chi sequence is a short stretch of DNA in the genome of a bacterium near which homologous recombination is unusually likely to occur.

The active site in many enzymes can be inhibited or suppressed by the presence of another molecule. There are three primary modes of inhibition.

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Because of the close relationship between biochemistry and medicine, I have included in this glossary a collection of prefixes, ...

Site
The position occupied by a mutation within the gene. (Cf. Locus.
Related Terms:
Mutation
The term which De Vries introduced into biological literature for an abrupt change of genotype which is inherited.

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Site devoted to the Cnidaria with illustrations
Bilaterians
All the remaining groups of animals belong in a clade whose members share: ...

Site-Directed Mutagenesis:
The introduction of a mutation, usually a point mutation or an insertion, into a particular location in a cloned DNA fragment.

site-specific A term used to describe any process or enzyme which acts at a defined sequence within a DNA or RNA molecule.

Site-directed mutagenesis. The process of introducing spe- cific base-pair mutations into a gene.

A site
The binding site for the aminoacyl-tRNA on the ribosome.
Atoll
A region of DNA that is absent on the chromosome of an organism but absent from closely related organisms (i.e., the opposite of a genetic island).

Cap site: Two usages: In eukaryotes, the cap site is the position in the gene at which transcription starts, and really should be called the "transcription initiation site".

Cap site: The initiation site of transcription in a eukaryotic gene. The initiation of translation of most eukaryotic mRNAs involves recognition of the cap followed by either the first downstream AUG or by a 5' proximal AUG with a consensus sequence ...

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Donor site see splice donor site.
Dosage compensation The imbalance caused by having two copies of the X chromosome in females compared to only one copy in males is countered (in humans) by X inactivation or (in Drosophila) by reducing the relative ...

A DNA site to which RNA polymerase will bind and initiate transcription.
Pronucleus
The nucleus of a sperm or egg prior to fertilization.
See also: nucleus, transgenic ...

active site
The specific portion of an enzyme that attaches to the substrate by means of weak chemical bonds.
active transport ...

poly A site The polyadenylation site defines the place in the gene where addition of a sequence of polyadenylic acid to the 3' end of an RNA after transcription will occur.

sink A site of collection of metabolites, such as sugar; metabolic sinks may exist anywhere in the plant where organic solutes are being transported by the phloem and stored.

This web site was initially set up for the use of my CSU Dominguez Hills students; however, I have had e-mails from people all over the world who have wandered into its pages. The web site was designed around my lecture notes.

leaves The site of photosynthesis; one of the three major organs in plants.
leukocytes White blood cells; primarily engaged in fighting infection.

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operator - site on DNA at which repressor protein binds to prevent transcription, e.g. in the lac operon.
organogenesis - creation of specific tissues and bodily organs by cell interaction and rearrangement following gastrulation.

Restriction site
Shortened term for restriction endonuclease recognition sequence.
Related Terms:
Restriction enzyme
A bacterially derived protein that recognizes specific, short nucleotide sequences and cuts DNA at those sites.

reservoir. The site where a pest population or quantity of inoculum can survive in the absence of a host crop, and from which a new crop may be invaded.
residue management. Management of rice straw and stubble after harvest.

Sequence Tagged Site
STS
Definition of STS
A unique sequence (typically less than 300 base-pairs) from a known chromosomal location identifying the position of a gene that can be amplified by PCR.

The exchange of DNA fragments between two DNA molecules or chromatids of paired chromosomes (during crossing over) at the site of identical nucleotide sequences. Homozygote.

The mitochondrial permeability transition (PT) pore, also called the mitochondrial megachannel, is a multiprotein complex formed at the contact site between the mitochondrial inner and outer membranes, exactly the same location at which Bax, ...

Promoter A short base sequence which is positioned close to the 5" end of a gene and acts as a recognition and binding site for the RNA polymerase complex prior to transcription of the gene.
RAPD Random amplification of polymorphic DNA.

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As with eukaryotes, the membrane controls the permeability of the cell and is the major site of energy metabolism.

The promoter and ribosome binding site codes in Eukaryotic DNA are likely to be different than those used by the host organism.

Epididymis coiled tubules‚ found within the scrotum‚ that store sperm and are the site of their final maturation
(epi = upon‚ over; didym = testes)
  
Epiglottis a flap above the larynx which closes to block off the trachea during swallowing ...

A ribosome is a cellular particle made of RNA and protein that serves as the site for protein synthesis in the cell.

- A nuclear organelle of eukaryotes, associated with the chromosomal site of genes coding for rRNA
Nucleosome
- The basic structural unit of eukaryotic chromosome, composed of an octomer and DNA ...

Recruitment. The residue of those larvae that have: (1) dispersed; (2) settled at the adult site; (3) made some final movements toward the adult habitat; (4) metamorphosed successfully, and (5) survived to be detected by the observer ...

nucleus -- Membrane-bound organelle which contains the DNA in the form of chromosomes. It is the site of DNA replication, and the site of RNA synthesis.

Restriction enzyme cutting site: A specific sequence of DNA at which a particular restriction enzyme cuts the DN A.

This page is part of the Developmental Biology ONLINE! web site. Special thanks to Tara McParland and Suzanne Gray for the preparation of this glossary.
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Department of Zoology, University of Guelph, Guelph, Ontario, Canada N1G 2W1.

The upper edge of the blastopore produced by invagination during gastrula formation in amphibian embryos; the site toward which surface cells of the gastrula converge and migrate inward along the roof of the blastocoel in the process of involution.

restriction nucleases - one of a large number of nucleases that can cleave a DNA molecule at any site where a specific short sequence of nucleotides occurs ...

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See also: Human, Genome, Environment, Genome project, Human Genome Project