Splicing (genetics)
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Splicing (genetics)
In genetics, splicing is a modification of genetic information prior to translation.
RNA splicing
a process or removing introns from nuclear RNA, thus converting it into a functional mRNA
Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row ...
trans-splicing
Splicing between different primary transcripts.
Related ...
Various ways of splicing out introns in eukaryotic pre-mRNAs resulting in one gene producing several different mRNAs and protein products.
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Splicing: See gene splicing.
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Splicing Processing a primary transcript into a mRNA by removal of the introns. It occurs within the nucleus.
RNA splicing
The removal of noncoding portions (introns) of the RNA molecule after initial synthesis.
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Gene splicing. Combining genes from different organisms into one organism. See recombinant DNA.
Gene translocation. The movement of a gene fragment from one chromosomal location to another, which often alters or abolishes expression.
Self-splicing RNA Refers to introns that have the ability to remove themselves from the precursor RNA and assist in the splicing of exons to form mature RNA.
splicing
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RNA splicing
A process by which introns are removed from primary See RNA transcripts leaving only exons that encode the amino acid sequence of a protein.
Related Terms:
Intron ...
The splicing reaction is self-contained; that is, the intron - with the help of associated proteins - splices itself out of the precursor RNA.
RNA splicing - RNA-processing step in which all of the intron sequences are removed and exon sequences are kept therebv producing a much shorter RNA molecule.
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RNA SPLICING - A complex and incompletly understood series of reactions occuring in the nucleus of eukaryotic cells in which pre-mRNA transcribed from chromosomal DNA is processed such that noncoding regions of the pre-mRNA (introns) are excised, ...
Alternative splicing is an important regulatory mechanism in higher eukaryotes1. By recent estimates, at least 30% of human genes are spliced alternatively (Mironov, A.A. and Gelfand, M.S. Proc. 1st Int. Conf.
Alternative splicing: Formation of diverse mRNAs through differential splicing of the same RNA precursor. This may result in proteins with different composition of amino acids or it may involve just the length of 3' UTR.
(See DNA polymorphism.) Alternative mRNA splicing. The inclusion or exclusion of different exons to form different mRNA transcripts. (See RNA.) Amino acid.
The process of genetic engineering involves splicing an area of a chromosome, a gene, that controls a certain characteristic of the body. The enzyme endonuclease is used to split a DNA sequence and split the gene from the rest of the chromosome.
Alternative splicing
One reason is that one gene may produce more than one mRNA. RNA splicing is the normal process in which intron sequences are removed from the pre-mRNA, producing the mRNA, which corresponds to the exons.
Ligation: The process of splicing two pieces of DNA together. In practice, a pool of DNA fragments are treated with ligase (see "Ligase") in the presence of ATP, and all possible splicing products are produced, ...
Examples include binding sites for transcription factors and splicing machinery.
Related Terms:
Nucleotide ...
A sequence of a gene which is transcribed but which is excised by a splicing reaction before the mature mRNA is translated. Found in Eukarya, Archae, Bacteria, eukaryotic viruses, and phage. Introns are common in eukaryotes, but rarer in prokaryotes.
Recombinant DNA: A form of DNA produced by splicing together segments of DNA from two or more organisms.
genetic engineering Modifying the genetic structure of one organism by splicing in selected genetic information from another organism.
Xu, et. al., Bacterial Origin of a Chloroplast Intron: Conserved Self-Splicing Group I Introns in Cyanobacteria, Science 250: 1566 - 1569
Kuhsel, et. al., An Ancient Group I Intron Shared by Eubacteria and Chloroplasts, Science 250: 1570 - 1572 ...
intron A segment of DNA in a gene that is transcribed but removed from the transcript by splicing together exon sequences from either side of the intron.
You might expect a change in size if you had an alteration in RNA splicing. The term northern blot actually is a play on words from how people originally would analyze DNA.
 See also: Protein, Trans, Gene, DNA, Sequence
  
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