Suppressor
A DNA sequence element to which transcriptional factors bind. Binding of transcriptional factors decreases gene transcription.
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Tumor Suppressor Gene
A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division. The tumor suppressor protein plays a role in keeping cell division in check.
Tumor Suppressor Genes
Some genes suppress tumor formation.
Their protein product inhibits mitosis.
When mutated, the mutant allele behaves as a recessive; that is, as long as the cell contains one normal allele, tumor suppression continues.
A mutant allele coding for a tRNA whose anticodon is altered in such a way that the suppressor tRNA inserts an amino acid at an amber codon in translation suppressing (preventing) termination.
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Suppressor mutation
A mutation that restores, partially or completely, the loss of function caused by another mutation.
suppressor T cell (TS)
A type of T cell that causes B cells as well as other cells to ignore antigens.
surface tension ...
suppressor T cells T cells that slow down and stop the immune response of B cells and other T cells. Immune system cells that shut off the antibody production when an infection is under control.
Suppressor gene A gene that can suppress the action of another gene.
Syndrome The group or recognizable pattern of symptoms or abnormalities that indicate a particular trait or disease.
tumor suppressor genes Genes that normally keep cell division under control, preventing the cell from responding to internal and external commands to divide.
Suppressor T cells do not promote immune function, but act to decrease it instead.
Tumor suppressor genes are genes with a wide variety of normal functions in the cell. I've always felt a little queasy about the idea of calling these tumor suppressor genes because it suggests that the gene evolved in order to suppress tumors.
Tumor suppressor: A gene that inhibits progression towards neoplastic transformation. The best-known examples of tumor suppressors are the proteins p53 and Rb.
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Tumour suppressor genes
Associated with cell division
Converted to oncogenes by mutation and reduce normal activity by inhibiting cell division
Might inhibit transcription of the proto-oncogenes like myc
May become overactive → tumour ...
An example of the important role that phosphorylation plays is the p53 tumor suppressor gene, which—when active—stimulates transcription of gene that suppress the cell cycle, even to the extent that it undergoes apoptosis.
p53 protein. A tumor suppressor protein with critical functions in normal cells. A mutation in the gene that encodes it, p53, can result in loss of control over cell division and thus cancer.
Cyclosporin A drug that is a potent suppressor of the immune system and is used to prevent rejection in organ transplants.
Mutated forms of these genes are believed to be responsible for about half the cases of inherited breast cancer, especially those that occur in younger women. Both are tumour suppressor genes. [Talking Glossary] ...
Important to the immune system, they produce circulating antibodies and T-lymphocytes, which are primarily responsible for cell-mediated immunity and can differentiate into helper, killer or suppressor cells.
In class I mutants, no mutation was evident in trpA -- evidently a suppressor mutation occured (a mutation in another gene, usually tRNA, to compensate for another mutation.) In the trpB region, all the classes had the correct mutation.
 See also: Protein, Cells, DNA, Trans, Cell
  
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