Tertiary Structure

Tertiary structure
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tertiary structure The folding of a protein's secondary structure into a functional three-dimensional con?guration. Shape assumed by protein due to interactions between amino acids far apart on the chain. PICTURE ...

tertiary structure - the three-dimensional structure of a polypeptide chain that results from the way that the alpha helices and beta pleated sheets are folded and arranged [Source: The Dictionary of Cell and Molecular Biology, Third Edition] ...

Tertiary structure
Tertiary structure refers to the overall 3-dimensional shape of the polypeptide chain.

Tertiary structure
Complex globular shape
Folding and twisting of polypeptides (H-bond)
Polypeptides contain many peptide bonds ...

tertiary structure (i.e. shape) in enzyme function and
noncovalent forces, e.g., ionic interactions and hydrogen bonds, in determining that shape.
Examples: ...

The tertiary structure of a protein refers to the:
A.
Sequence of amino acids ...

Their tertiary structure gives them a globular shape
(not to scale, remember, proteins are each made out of 100's of amino acids) ...

Often refers to breaking hydrogen bonds between base pairs in double-stranded nucleic acid molecules to produce in single-stranded polynucleotides or altering the secondary and tertiary structure of a protein, destroying its activity.

The tertiary structure is controlled by bonding (or in some cases repulsion) between R-groups. Tertiary structure of an HIV protein and its similarity to gamma interferon are shown in Figure 22.

In addition to the tertiary structure of the subunits, multiple-subunit proteins possess a quaternary structure, which is the arrangement into which the subunits assemble.

Domain An independently folded unit in the tertiary structure of a polypeptide chain; may contain a number of supersecondary structures. In multienzyme complexes, each domain may carry out one or more catalytic reactions.

These helices, strands, turns, and coils interact chemically with each other to form the unique three-dimensional shape of the protein, called the tertiary structure.

In proteins, it refers to disruptions in the secondary and tertiary structure of the protein, destroying its activity.
Related Terms:
Structural change ...

Domain: Region of a protein with a distinct tertiary structure and characteristic activity (for example, the membrane distal and membrane proximal domains of an MHC molecule).

These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues.

Denaturation - of DNA - conversion from double stranded to single stranded form, often by heating sometimes by treatment with alkali. - of protein - treatment which destroys the tertiary structure of a protein.
Deoxyribonucleic acid see DNA ...

In DNA it refers to the separation of the two component strands caused by the breaking of the hydrogen bonds. In proteins, it refers to disruptions in the secondary and tertiary structure of the protein, destroying its activity.

See also: Protein, Proteins, Molecule, Acids, Enzyme