Topoisomerase
An enzyme which introduces or removes overwinding or underwinding of the DNA circular duplex by causing a nick, rotating the strands, and then ligating them.
Topoisomerases and helicases
Topoisomerases are enzymes with both nuclease and ligase activity. These proteins change the amount of supercoiling in DNA.
A topoisomerase that relieves supercoiling in DNA by creating a transient break in the double helix.
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The topoisomerases in eukaryotes are not affected.
Polypeptides
The most common of these are the polymixins.
DNA gyrase A topoisomerase that catalyzes the ATP-driven introduction of negative supercoils into DNA. Also called topoisomerase II.
The addition of ThermoFidelase 2 with its unique combination of topoisomerase and DNA binding activities is used to shorten the cycles of denaturation and primer annealing.
 See also: DNA, Trans, Enzyme, Cell, Gene
  
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