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Transcription start site

Biology  Transcription factors  Transcription unit
04/21/2014

Transcription start site
This is where a molecule of RNA polymerase II (pol II, also known as RNAP II) binds. Pol II is a complex of 12 different proteins (shown in the figure in yellow with small colored circles superimposed on it).


Transcription Start Site (TSS)
Approximately -35
A binding site for RNA polymerase ...

At most yeast promoters, the region directly upstream of the transcription start site contains transcription factor binding sites and is nucleosome-free, increasing the accessibility of the binding sites to transcriptional regulators [49] (Figure 1).

A sequence on DNA that functions as the RNA polymerase binding site, thus defining the transcription start site.

A regulatory region a short distance upstream from the 5' end of a transcription start site that acts as the binding site for RNA polymerase. A region of DNA to which RNA polymerase binds in order to initiate transcription.

Sequences on the 5' end of mRNA but not translated into protein. It extends from the transcription start site to just before the ATG translation initiation codon. 5' UTR may contain sequences that regulate translation efficiency or mRNA stability.

Where RNA polymerase starts transcribing RNA is known as the transcription start site. Where it falls off the DNA, and so stops transcribing RNA, is known as the transcription termination site.

They are ubiquitous and interact with the core promoter region surrounding the transcription start site(s) of all class II genes.[8] ...

A region of DNA extending 150-300 bp upstream from the transcription start site that contains binding sites for RNA polymerase and a number of proteins that regulate the rate of transcription of the adjacent gene. (See Constitutive promoter.) ...

- A sequence located approximately 75 base-pairs upstream from eukaryotic transcription start sites. This sequence is one of those that enhance binding of RNA polymerase
Cacao ...

Any regulatory sequence in eukaryotic DNA that is located within ≈200 base pairs of the transcription start site. Transcription of many genes is controlled by multiple promoter-proximal elements. (Figure 10-34) ...

Origin
Short for origin of replication. The specific nucleotide sequence at which DNA synthesis is initiated. Cf. transcription start site and terminator.

Pribnow box
Relatively invariant sequence of six nucleotides (consensus TATAAT) in prokaryotic promoters centred at the position minus 10 (10 base pairs upstream from the transcription start site). In eukaryotes the analogous is called TATA box.

generally take the form of associations of data such as genes, to keywords such as GO terms that describe the function, subcellular localization and processes involving the gene product. Structural annotations (e.g. transcription start sites, exons, ...

upstream of the gene that might help enhance or repress the particular gene that's about to be transcribed in certain cell types. In general, if you think of the promoter as that piece of DNA that's just upstream of the transcription start site of a ...

See also: See also: Transcription, Transcript, Trans, Sequence, DNA

Biology  Transcription factors  Transcription unit
04/21/2014

 
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