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Transcription start site

Biology  Transcription factors  Transcription unit

Transcription start site
This is where a molecule of RNA polymerase II (pol II, also known as RNAP II) binds. Pol II is a complex of 12 different proteins (shown in the figure in yellow with small colored circles superimposed on it).


Transcription start site PolII signal is correlated with DNA sequence and RNA expression ...

Transcription start site
Site within a gene where transcription of RNA begins.
Related Terms:
Gene
The term coined by Johannsen (1909) for the fundamental physical and functional unit of heredity.

Transcription Start Site (TSS)
Approximately -35
A binding site for RNA polymerase
RNA-polymerase I: transcribes genes encoding ribosomal RNA
RNA-polymerase II: transcribes genes encoding mRNA and certain small nuclear RNAs ...

transcription start site. Interestingly, although most of the basic transcription factors are not shared between the three polymerases, TBP, which was first discovered as a protein involved in RNA polymerase II transcription, ...

At most yeast promoters, the region directly upstream of the ~ contains transcription factor binding sites and is nucleosome-free, increasing the accessibility of the binding sites to transcriptional regulators [49] (Figure 1).

Where RNA polymerase starts transcribing RNA is known as the ~. Where it falls off the DNA, and so stops transcribing RNA, is known as the transcription termination site.
As transcription initiates, the RNA polymerase moves away from the ~.

A sequence on DNA that functions as the RNA polymerase binding site, thus defining the ~. Promoter recognition is largely determined by the sigma factor associated with RNA polymerase and the interaction of RNA polymerase with positive regulatory proteins.

A regulatory region a short distance upstream from the 5' end of a ~ that acts as the binding site for RNA polymerase. A region of DNA to which RNA polymerase binds in order to initiate transcription.

Sequences on the 5' end of mRNA but not translated into protein. It extends from the ~ to just before the ATG translation initiation codon. 5' UTR may contain sequences that regulate translation efficiency or mRNA stability.
Related ...

They are ubiquitous and interact with the core promoter region surrounding the ~(s) of all class II genes.[8]
Upstream transcription factors are proteins that bind somewhere upstream of the initiation site to stimulate or repress transcription.

- A sequence located approximately 75 base-pairs upstream from eukaryotic ~s. This sequence is one of those that enhance binding of RNA polymerase
Cacao ...

Any regulatory sequence in eukaryotic DNA that is located within ≈200 base pairs of the ~. Transcription of many genes is controlled by multiple promoter-proximal elements. (Figure 10-34) ...

Origin
Short for origin of replication. The specific nucleotide sequence at which DNA synthesis is initiated. Cf. ~ and terminator.

Functional annotations generally take the form of associations of data such as genes, to keywords such as GO terms that describe the function, subcellular localization and processes involving the gene product. Structural annotations (e.g. ~s, exons, introns, protein domains) ...

region that might include sequences that are farther upstream of the gene that might help enhance or repress the particular gene that's about to be transcribed in certain cell types. In general, if you think of the promoter as that piece of DNA that's just upstream of the ~ of ...

A region of DNA extending 150-300 bp upstream from the ~ that contains binding sites for RNA polymerase and a number of proteins that regulate the rate of transcription of the adjacent gene. (See Constitutive promoter.) Pronucleus.

See also: See also: What is the meaning of Transcript, Transcription, Trans, Sequence, DNA?

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