Transgenic mouse
A mouse which carries experimentally introduced DNA in its genome. Linear DNA is injected into a fertilized embryo at the pro-nuclear stage and may be incorporated into the genome.
Chapter 18
Transgenic mouse models of Alzheimer's disease:phenotype and mechanisms of pathogenesis
Karen Duff
Nathan Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY 10962, U.S.A.
Transgenic mouse: A mouse which carries experimentally introduced DNA. The procedure by which one makes a transgenic mouse involves the injection of DNA into a fertilized embryo at the pro-nuclear stage.
A transgenic mouse has been created carrying a single copy of a mutant fibrillin 1, a mutation similar to that found in the human fibrillin 1 gene that is known to cause Marfan syndrome.
Chromosome 19 sequence data are analyzed and used to generate targeting constructs in making transgenic mouse models and for characterizing the structure and function of these repair genes.
The graph shows the results of a test done on the spleen cells of a transgenic mouse that had been dosed with benzopyrene, a known mutagen (and carcinogen).
 See also: Trans, Mouse, Transgenic, Human, Genome
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