Tumor suppressor

Tumor Suppressor Genes
Some genes suppress tumor formation.
Their protein product inhibits mitosis.
When mutated, the mutant allele behaves as a recessive; that is, as long as the cell contains one normal allele, tumor suppression continues.

Tumor suppressor
Tumor suppressor genes inhibit progression in tumor development. They usually inhibit abnormal cell growth or promote apoptosis. Examples include p53 and Rb.
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Tumor Suppressor Gene
A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division. The tumor suppressor protein plays a role in keeping cell division in check.

Tumor Suppressor
BRCA1 is believed to act as a tumor suppressor regulating cell growth and division. If suppressor genes are lost or damaged by mutation, uncontrolled cell growth can occur, resulting in cancer.

tumor suppressor genes Genes that normally keep cell division under control, preventing the cell from responding to internal and external commands to divide.

tumor suppressor gene
A gene whose protein products inhibit cell division, thereby preventing uncontrolled cell growth (cancer).
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[edit] Tumor suppressor genes
Main article: Tumor suppressor gene
Under normal conditions, tumor suppressor genes regulate cellular differentiation and suppression of proliferation.

Tumor suppressor genes are genes with a wide variety of normal functions in the cell. I've always felt a little queasy about the idea of calling these tumor suppressor genes because it suggests that the gene evolved in order to suppress tumors.

Tumor suppressor: A gene that inhibits progression towards neoplastic transformation. The best-known examples of tumor suppressors are the proteins p53 and Rb.
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p53 protein. A tumor suppressor protein with critical functions in normal cells. A mutation in the gene that encodes it, p53, can result in loss of control over cell division and thus cancer.

An example of the important role that phosphorylation plays is the p53 tumor suppressor gene, which—when active—stimulates transcription of gene that suppress the cell cycle, even to the extent that it undergoes apoptosis.

Breast cancer prognosis is associated with a tumor suppressor gene called p27.
Carcinogens
Carcinogens are chemicals that cause cancer by causing mutations.

Tumor suppressor gene -- genes that normally function to restrain the growth of tumors; the best understood case is for hereditary retinoblastoma.

See also: Suppressor, Tumor, Protein, Cancer, Cells