Xeroderma pigmentosum is a genetic disease in which some repair enzymes do not function.
Organization of DNA
Chromosome Structure ...
Mutation in this gene leads to one form of the disease syndrome xeroderma pigmentosum. Homologs of the XPF protein are present in fly, worm, plant, yeast and archea, indicating conservation of an essential function throughout all of evolution.
Another example is when germline mutations in genes coding for DNA repair enzymes cause hereditary cancer syndromes such as xeroderma pigmentosum. Defects in these enzymes cause cancer since the body is less able to repair mutations in the genome.
[More] Xeroderma pigmentosum (XP)and aging X inactivation[Described] [role of XIST locus] X linkage X-linked adrenoleukodystrophy (X-ALD) X-linked agammaglobulinemia X-linked SCID Xylem[ transport in ] [in roots]
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A defect in a DNA repair gene called XP (Xeroderma pigmentosum) results in individuals who are very sensitive to UV light and have a thousand-fold increase in the incidence of all types of skin cancer.
 See also: Pigment, Mutation, Human, Trans, Environment
  
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