Acute megakaryoblastic leukemia

Acute megakaryoblastic leukemia
Overview
Acute megacaryoblastic leukemia: A rare form of malignant bone marrow cancer involving the proliferation of immature precursors of blood cells.

Acute megakaryoblastic leukemia (AMKL) is a form of leukemia where a majority of the blasts are megakaryoblastic.[1]
It is classified under M7 in the French-American-British classification.[2] ...

Acute megakaryoblastic leukemia (FAB Classification M7)
Acute megakaryoblastic leukemia, in which 50% or more of blasts are of the megakaryocyte lineage, occurs in all age groups and comprises approximately 3% to 5% of cases of AML.

Acute megakaryoblastic leukemia (previously called M7)
Acute basophilic leukemia
Acute panmyelosis with myelofibrosis ...

: The t(1;22) (p13;q13) is nonrandom and restricted to infants with acute megakaryoblastic leukemia: a Pediatric Oncology Group Study. Blood 78 (3): 748-52, 1991.
Lion T, Haas OA: Acute megakaryocytic leukemia with the t(1;22)(p13;q13).

Acute megakaryoblastic leukemia. Leuk Lymphoma. 1995;18 Suppl 1:69-73. Abstract
â†' Redaelli A, Stephens JM, Laskin BL, Pashos CL, Botteman MF. The burden and outcomes associated with four leukemias: AML, ALL, CLL and CML.

Fewer than 100 cases of pediatric MF have been reported worldwide. This is likely an under-representation because cases associated with acute megakaryoblastic leukemia (the most common association) are not generally reportable.

See also: Leukemia, Acute lymphoblastic, Acute lymphoblastic leukemia, Cancer, Acute promyelocytic leukemia