Alanine transaminase (ALT) is an enzyme found in the highest amounts in the liver. Injury to the liver results in release of the substance into the blood.
Alternate Names : SGPT, Serum glutamate pyruvate transaminase, Alanine transaminase
ALT is present in many different kinds of tissue in the body. However, it is highly concentrated in the liver. Therefore, when the liver is injured, ALT is released into the bloodstream.
Review Date: 02/22/2009
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine.
An increase in ALT levels may be due to:
Death of liver tissue (liver necrosis)
Hepatitis (viral, autoimmune)
Infectious mononucleosis ...
An increase in levels may be due to:
Cirrhosis (scarring of the liver)
Death of liver tissue (liver necrosis)
Lack of blood flow to the liver (liver ischemia)
Liver tumor or cancer
Medications that are toxic to the liver ...
The ALT test is often done along with other tests that check for liver damage, including aspartate aminotransferase (AST), alkaline phosphatase, lactate dehydrogenase (LDH), and bilirubin. Both ALT and AST levels are reliable tests for liver damage.
Abbreviation: ' '
Category: Common Medical Abbreviations
Meaning: Alanine Transaminase ...
See "Alanine aminotransferase"
1. In a trial, the alternative hypothesis might be that a treatment of unknown efficacy has more benefit than the standard treatment.
(alanine aminotransferase) - An enzyme normally produced by the liver; blood levels may increase in cases of liver damage; formerly known as SGPT.
Anti-HAV - Antibody to hepatitis A virus.
ALT (alanine aminotransferase): An enzyme normally present in liver and heart cells that is released into the bloodstream when the liver or heart is damaged from, for example, viral hepatitis or a heart attack).
(alanine aminotransferase) definition - Health and Medical Information produced by doctors - MedicineNet.com
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ALT is an enzyme found mainly in liver cells, although smaller amounts are also in other organs of the body. When the liver becomes damaged, this enzyme leaks into the blood. A blood test can measure the level of ALT in the blood.
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ALT is an enzyme that transfers an amino group from the amino acid alanine to a ketoacid acceptor (oxaloacetate). The enzyme was formerly called serum glutamic pyruvic transaminase (SGPT) after the products formed by this reaction.
relatively lower than AST in alcoholism
Assess severity/chronicity ...
ALT: see alanine aminotransferase.
ALTERNATIVE THERAPY: any type of treatment that is not considered standard or conventional practice in a given culture.
(SGPT) is, by contrast, normally found largely in the liver. This is not to say that it is exclusively located in liver, but that is where it is most concentrated. It is released into the bloodstream as the result of liver injury.
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This section requires expansion.
(SGPT) must be performed at baseline and monitored at monthly intervals during the first six months then, if stable, every 6 to 8 weeks thereafter.
ALT = alanine aminotransferase; AST = aspartate aminotransferase; HSCT = hematopoietic stem cell transplantation.
Methotrexate; mercaptopurine/thioguanine; HSCT
Hepatic dysfunction ...
During surgery, a laser makes tiny, evenly spaced burns in the trabecular meshwork. The laser does not create new drainage holes, but rather stimulates the drain to function more efficiently.
Spinal tap (lumbar puncture)'insertion of a needle between the lumbar vertebrae in the back to remove spinal fluid for testing
Liver biopsy 'removal of a sample of liver tissue for testing ...
The liver enzymes ( and AST) may be elevated in chronic hepatitis C infection. in HCV is not correlated with disease progression or underlying histology. Many patients with chronic hepatitis C have normal levels.
Alanine aminotransferase (ALT). This enzyme, found in the liver, plays a role in metabolism, the process that converts food into energy. If the liver is injured, ALT is released into the bloodstream.
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Alanine transaminase (ALT). This is an enzyme that helps to process proteins. (An enzyme is a protein that helps to speed up chemical reactions. Various enzymes occur in the cells in the body.) Large amounts of ALT occur in liver cells.
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Elevation of liver enzymes (alkaline phosphatase, LDH, and ) suggests the presence of liver metastases. Elevated alkaline phosphatase and serum Ca may be the first evidence of bone metastases.
NASH is usually first suspected in a person who is found to have elevations in liver tests that are included in routine blood test panels, such as alanine aminotransferase (ALT) or aspartate aminotransferase (AST).
Normal Levels of AST and
Elevated Levels of AST and
Diseases That Cause Abnormal Aminotransferase Levels
Medications That Cause Abnormal Aminotransferase Levels
Less Common Causes of Abnormal Aminotransferase Levels ...
Tests: Blood tests of liver function show significantly elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, and bilirubin.
See also: AST, Hepatitis, Cancer, Liver disease, Viral