Beta-thalassemia

Beta-thalassemia (the most common form of this disorder) occurs in three clinical forms: thalassemia major, intermedia, and minor.

Sickle Cell Beta-thalassemia
MARCM
Mosaic Analysis With A Repressible Cell Marker ...

Hemoglobin S-beta-thalassemia
This involves an inheritance of both the thalassemia and sickle cell genes. The disorder produces symptoms of moderate anemia and many of the same conditions associated with sickle cell disease.

Individuals with beta-thalassemia major (the most severe form of thalassemia), can live into their fifties with blood transfusions, iron chelation therapy, and splenectomy.

It is known as beta-thalassemia, because of an imbalance in the beta chain amino acids of hemoglobin. It also involves the persistence of HbF with larger than normal amounts appearing in the child's circulation.

Alpha-thalassemia, alpha thalassemia major, alpha thalassemia minor, alpha thalassemia trait, anemia, beta-thalassemia, beta thalassemia intermedia, beta thalassemia minor, Cooley's anemia, erythroblastic anemia, hemoglobin H disease, ...

Hemoglobin sickle beta-thalassemiaEach of these can cause sickle pain episodes and complications, but some are more common than others.

from severe chronic anemias and those with beta-thalassemia need ... problem they frequently encounter is that due to transfusions ... the body. This results in heart and liver failure. ... is a time consuming process.

GeneReviews
Gene Tests: Hemoglobin S Beta-Thalassemia
Gene Tests: Hemoglobin SC
Gene Tests: Hemoglobin SD
Gene Tests: Hemoglobin SS
MedlinePlus Encyclopedia: Sickle cell anemia
MedlinePlus Encyclopedia: Sickle cell test ...

Rund D, Rachmilewitz E; Beta-thalassemia. N Engl J Med. 2005 Sep 15;353(11):1135-46.
Chart showing risk rates for carrying haemoglobin disorders, according to family origin. Darlisson M, Modell B, 2004.

Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L, et al. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood. 2006 May 1;107(9):3455-62.

For example, first cousins of Italian descent are at increased risk of carrying a gene for beta thalassemia and genetic laboratory tests may confirm that they are both beta-thalassemia gene carriers.

Hydrops fetalis syndrome due to Beta-thalassemia ... still birth
Hyperinsulinemic hypoglycemia, familial, 1 ... low birth weight
Hyperinsulinemic hypoglycemia, familial, 2 ... low birth weight
Hypomandibular faciocranial dysostosis ...

See also: Thalassemia, Anemia, Infections, Symptom, Surgery