The cardinal sign of cord injury is a discrete injury level in which neurologic function above the injury is intact, and function below the injury is absent or markedly diminished.
"Amyotrophic" refers to the loss of muscle bulk, a cardinal sign of ALS. "Lateral" indicates one of the regions of the spinal cord affected, and "sclerosis" describes the hardened tissue that develops in place of healthy nerves.
Around AD 30, Aulus Cornelius Celsus described the four cardinal signs of inflammation as rubor (redness), calor (heat), dolor (pain), and tumor (swelling), and recommended that a boiled vinegar extract of willow leaves could be used for pain relief.
The typical signs and symptoms associated with an ankle sprain are the cardinal signs of inflammation:
localized pain
swelling
loss of function ...
Being a localised acute inflammatory response, the four signs of Celsus are displayed [1][2]. Marked pitting oedema (tumor) affects hand, usually sparing the wrist and digits due to the spacious dorsal compartment. The cardinal signs of calor, ...
A series of changes in tissues indicating their reaction to injury, whether mechanical, chemical or bacterial. The cardinal signs are: heat, swelling, pain and redness
Inflammatory Disease
A disease characterized by inflammation ...
Cardinal signs may be absent, e.g., meningitis with opportunistic pathogens without meningismus in 63%, and pneumonia without purulent sputum in 92%.
 See also: Symptom, Injuries, Prevention, Trauma, Injury
  
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