Crigler-Najjar Syndrome

Crigler-Najjar syndrome
Definition
Crigler-Najjar syndrome is a very rare inherited disorder in which bilirubin (a substance made by the liver) cannot be broken down.

Crigler-Najjar syndrome
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Crigler-Najjar syndrome
Alternate Names : Glucuronyl transferase deficiency (type I Crigler-Najjar), Arias syndrome (type II Crigler-Najjar)
Definition ...

Crigler-Najjar Syndrome
Crigler-Najjar Syndrome or CNS is a rare disorder affecting the metabolism of bilirubin, a chemical formed from the breakdown of blood.

Crigler-Najjar syndrome is caused by an abnormal gene. The gene fails to make the enzyme that normally converts bilirubin into a form that can easily be removed from the body.

Crigler-Najjar syndrome is a rare genetic disorder characterized by elevated levels of bilirubin in the blood (hyperbilirubinemia).

Crigler-Najjar syndrome and Lucey-Driscoll syndrome are also conditions that can cause jaundice.
A condition called carotenemia also causes a yellowish discoloration of the skin.

Crigler-Najjar Syndrome
Primary Shunt Hyperbilirubinemia
Dubin-Johnson Syndrome and Rotor's Syndrome ...

Crigler-Najjar syndrome
Diagnostic approach to the patient with jaundice or asymptomatic hyperbilirubinemia
Evaluation of unconjugated hyperbilirubinemia in term and late preterm infants ...

This is distinguished from Crigler-Najjar syndrome type II, in which patients have total serum bilirubin levels between 6 and 20 mg/dL, and Crigler-Najjar syndrome type I, in which patients have total serum bilirubin levels from 20 to 45 mg/dL.

There may be inherited genetic problems with the enzymes that convert or break down bilirubin - these include rare conditions such as Crigler-Najjar syndrome, Gilbert's syndrome, galactosaemia and tyrosinaemia.

The gene is located on chromosome 2. Other types of mutations in the same gene cause the Crigler-Najjar syndrome, which is a more severe and dangerous form of hyperbilirubinemia (high bilirubin in the blood).

Crigler-Najjar syndrome see Liver disease
Crohn's disease and Ulcerative Colitis
Crouzon syndrome
Cryptorchidism-shortness of stature-obesity-subnormal mentality see Prader-Willi syndrome
Cushing syndrome/disease
Cutaneous Porphyrias see Porphyria ...

Biliary atresia
Hemolytic anemia
Disorders present since birth that cause problems processing bilirubin such as Gibert's syndrome, Dubin-Johnson syndrome, Rotor's syndrome or Crigler-Najjar syndrome ...

This occurs in a disease called Crigler-Najjar syndrome.
Problems with digesting galactose: Babies who cannot normally break down the sugar in breast milk (lactose) or in some formulas that contain cow's milk may have a disease called galactosemia.

cri-du-chat syndrome
Crigler-Najjar syndrome
crocodile tears syndrome
Crouzon's syndrome
Cruveilhier-Baumgarten syndrome
cryptophthalmus syndrome
Cushing's syndrome
Cushing syndrome
cutaneomucouveal syndrome ...

Crigler-Najjar syndrome, type 1 ... recurrent fever
Crisponi syndrome ... fever
CRMO, juvenile ... fever
Crohn's disease ... fever
Crotalidae snake poisoning ... chills
Croup ... fever
Cryophobia ... trembling
Cryptococcal Meningitis ... fever ...

See also: Jaundice, Deficiency, Symptom, Fusion, Cancer