Hyperhomocysteinemia
Possible cause
Due to folate, vitamin B12, or vitamin B6 deficiency ...
Hyperhomocysteinemia is a medical condition that is characterized by high levels of an amino acid, called homocysteine, in the blood. Patients with hyperhomocysteinemia have an increased risk of developing coronary artery disease (CAD).
Hyperhomocysteinemia is associated with an increased risk of <><><><><><> cardiovascular disease, especially in non-<><><><><><> insulin-dependent diabetes mellitus: a population-based study. Arterioscler Thromb Vasc Biol. Jan 1998;18(1):133-138.
Theoretically, an elevated level of homocysteine in the blood (hyperhomocysteinemia) is believed to cause narrowing and hardening of the arteries (atherosclerosis).
About one in every seven patients in the IBD group had hyperhomocysteinemia. As expected, those with vitamin B12 deficiency tended to have higher homocysteine levels.
11. Stammler F, Diehm C, Hsu E, et al. The prevalence of hyperhomocysteinemia in thromboangiitis obliterans. Does homocysteine play a role pathogenetically? Dtsch Med Wochenschr 1996;121:1417-23 [in German].
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Balasa, W., K. A. Kalinyak, J. A. Bean, et al. "Hyperhomocysteinemia is Associated with Low Plasma Pyridoxine Levels in Children with Sickle Cell Disease." Journal of Pediatric Hematology and Oncology 24 (June-July 2002): 374-9.
Booth GL, Wang EE. Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care. CMAJ. 2000;163(1):21-29.
Anticardiolipin antibodies (ACA) or beta-2 glycoproteins, which are part of the antiphospholipid antibody syndrome
Lupus anticoagulants (LA), part of the antiphospholipid antibody syndrome
Fasting plasma homocysteine levels
Hyperhomocysteinemia ...
 See also: Symptom, Deficiency, Folic Acid, Stroke, Nutrition
  
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