Gout / Hyperuricemia: Overview
Known as "the disease of kings and the king of diseases", gout has been studied by physicians and has caused suffering in countless humans since at least the days of Hippocrates.
Alternate Names : Gouty arthritis - acute, Gout - acute, Hyperuricemia, Tophaceous gout, Tophi, Podagra, Gout - chronic, Chronic gout, Acute gout, Acute gouty arthritis
Gout is a kind of arthritis that occurs when uric acid builds up in the joints.
hyperuricemia A buildup of uric acid (a byproduct of metabolism) in the blood; a side effect of some anticancer drugs.
hypervascular Having a large number of blood vessels.
hypnosis A trance-like state in which a person becomes more aware and focused and is more open to suggestion.
Hyperuricemia or acute gout may be precipitated in certain patients receiving thiazide diuretics. Bisoprolol, alone or in combination with HCTZ, has been associated with increases in uric acid. However, in U.S.
Hyperuricemia: Abnormally elevated blood level of uric acid. Uric acid is a breakdown product of purines that are part of many foods we eat. While hyperuricemia may indicate an increased risk of gout , the relationship between hyperuricemia and gout is unclear.
~ is not the same as gout. Asymptomatic ~ does not need to be treated.
Risk factors for gout include being overweight or obese, having hypertension, alcohol intake (beer and spirits more than wine), diuretic use, and a diet rich in meat and seafood. (4,5,6) ...
~ is the disorder that occurs when you have too much uric acid in the body. Increased cell death, because of cancer or cancer treatments, can also lead to an accumulation of uric acid in the body. It is also possible to have too little uric acid in the body, called hypouricemia.
Presence of uric acid crystals in joint fluid
More than one attack of acute arthritis ...
~ Rates Remain High Among U.S. Adults And Senior Citizens Placing Them At Risk For Developing Gout
The Number Of People With Gout Continues To Rise
Urate Lowering Therapy Could Prevent Death Associated With Cardiovascular Disease In People With Gout ...
~ (high level of uric acid in the blood)
Uric acid crystals in joint fluid
More than one attack of acute arthritis
Arthritis that develops in 1 day, producing a swollen, red, and warm joint
Attack of arthritis in only one joint, usually the toe, ankle, or knee.
~ (> 15 mg/dL)
Hyperphosphatemia (> 8 mg/dL)
Allopurinol Some Trade Names
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(200 to 400 mg/m2 once/day, maximum 600 mg/day) and normal saline IV to achieve urine output > 2 L/day should be initiated with close laboratory and cardiac monitoring.
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In ~, blood uric acid levels are raised because of the increased endogenous production and reduced urinary elimination caused by competition with the elevated concentrations of lactate, which should be excreted.
Note: ~ does not inevitably lead to gout. In fact, less than 20% of cases turn out to be full-blown arthritic gout disease.
Symptoms of Acute Gouty Arthritis ...
Uric Acid and ~. Purines in the liver produce uric acid. The uric acid enters the bloodstream, and most of it eventually goes through the kidneys and is excreted in the urine. The remaining uric acid travels through the intestines, where bacteria help break it down.
Metabolic: ~, diabetes mellitus
Musculoskeletal: joint pain, myalgia, osteonecrosis, osteoporosis (with long-term use in children)
Respiratory: dry nonproductive cough, pneumonitis, pulmonary fibrosis, pulmonary interstitial infiltrates ...
Chronic subclinical lead exposure is associated with interstitial nephritis, tubular damage (with tubular inclusion bodies), ~ (with an increased risk of gout), and a decline in glomerular filtration rate and chronic renal failure.
Most people with ~ never develop gout, and people with gout may have varying levels of uric acid in their blood.
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What is ~?
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~ (HY-per-yur-ih-SEE-mee-uh) A buildup of uric acid (a byproduct of metabolism) in the blood. ~ is a side effect of some anticancer drugs.
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hypervascular (HY-per-VAS-kyoo-ler) Having a large number of blood vessels.
'Total Purine and Purine Base Content of Common Foodstuffs for Facilitating Nutritional Therapy for Gout and ~.' Biological and Pharmaceutical Bulletin. 2014; 37 (5); pages 709-21. . Accessed June 2014.
Zhang Y., DSc, Neogi T., MD PhD FRCPC, Chen C., MHS, et al.
If there is an increase in the production of uric acid or if the kidneys do not eliminate enough uric acid from the body, levels of it build up in the blood (a condition called ~).
Gout is characterized by ~, recurrent acute arthritis and, often deposition of urates in the skin as nodules, known as gouty tophi; yellow red papules tending to coalesce into multilocular nodules and plaques, most commonly on the helix and ante-helix of the ear and on the fingers.
Although most people with gout have ~, about 3 in 10 turn out to have normal uric acid levels during an actual attack. Meanwhile, ~ by itself doesn't mean that a person will develop gout - less than 1 in 5 people with high uric acid end up with gout.
If you have gout and ~, your body doesn't eliminate enough uric acid.
Risk Factors TOP
These factors increase your chance of developing gout. All causes of ~ are risk factors for gout.
In gout, there are frequently, but not always, elevated levels of uric acid in the blood (~). However, only a small portion of those with ~ will develop gout.
Search results Medical News for - Uric acid ...
On the most basic level, gout is caused by too much uric acid in the blood, a condition called ~. This condition can be caused either by too much dietary intake of chemicals that break down into uric acid or by kidney problems that make the body less able to remove uric acid.
If you have experienced a gout attack or have high uric acid in your blood (~), it may help to reduce your intake of meat, seafood, and alcohol. footnote 1 ...
Animal proteins, arthritis, corticosteroids, gouty arthritis, kidney disease, kidney failure, kidney stones, ~, nonsteroidal anti-inflammatory drugs, NSAIDs, podagra, pseudogout, purines, tophi, urate crystals, uric acid.
Other clinical manifestations include ~, intellectual disability, a dystonic movement disorder that may be accompanied by choreoathetosis and spasticity, dysarthric speech, and compulsive self-biting, usually beginning with the eruption of teeth.
They can also have a buildup of lactic acid in the body (lactic acidosis), high blood levels of a waste product called uric acid (~), and excess amounts of fats in the blood (hyperlipidemia). As they get older, children with GSDI have thin arms and legs and short stature.
Blood tests may also reveal high cholesterol, high fats (hyperlipidemia), and elevated uric acid levels (~). Thyroid-stimulating hormone (TSH) should be measured to exclude thyroid deficiency.
Malignancy may lead to pain, wasting, neuropathy, nausea, anorexia, seizures, hypercalcemia, ~, obstruction, and organ failure.
Predisposing factors may include recent reduction in fluid intake, increased exercise with dehydration, medications that cause ~ (high uric acid) and a history of gout. Treatment includes relief of pain, hydration and, if there is concurrent urinary infection, antibiotics.
Most uric acid dissolves in blood and travels to the kidneys, where it passes out in urine. If your body produces too much uric acid or doesn't remove enough if it, you can get sick. High levels of uric acid in the body is called ~.
It may also be due to tubular damage from excretion of light chains, also called Bence Jones proteins, which can manifest as the Fanconi syndrome (type II renal tubular acidosis). Other causes include glomerular deposition of amyloid, ~, recurrent infections (pyelonephritis), ...
Uric acid is normally found in the body as a normal byproduct of the way the body breaks down certain proteins called purines. Causes of an elevated blood uric acid level (~) include genetics, obesity, certain medications such as diuretics (water pills), ...
The combination of interstitial fibrosis and hyaline casts surrounded by epithelial cells or multinucleate giant cells constitutes myeloma kidney. Additionally, hypercalcemia and hypercalciuria as well as ~ contribute to kidney damage.
After repeated phlebotomies, the patient develops iron deficiency, which stabilizes RBC production and reduces the need for phlebotomy. Phlebotomy doesn't reduce the WBC or platelet count and won't control the ~ associated with marrow cell proliferation.
See also: What is the meaning of Kidney, Gout, Nausea, Blood pressure, Vomiting?