Kearns-Sayre syndrome

Kearns-Sayre Syndrome
This disorder was first reported by Thomas P. Kearns, and George P. Sayre in 1958. It has since been diagnosed in many families and has important ocular as well as systemic abnormalities.
Clinical Correlations ...

NINDS Kearns-Sayre Syndrome Information Page
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(Kearns-Sayre Syndrome; Leigh's Syndrome; Mitochondrial DNA Depletion Syndrome; Mitochondrial Encephalomyopathy, Lactic Acidosis and Strokelike Episodes; Myoclonic Epilepsy Associated With Ragged Red Fibers; ...

(Kearns-Sayre Syndrome; Leigh's Syndrome; Mitochondrial DNA Depletion Syndrome; Mitochondrial Encephalomyopathy, Lactic Acidosis and Strokelike Episodes; Myoclonic Epilepsy Associated With Ragged Red Fibers; ...

Kearns-Sayre Syndrome is a rare neuromuscular disorder characterized by three primary findings: progressive paralysis of certain eye muscles (chronic progressive external ophthalmoplegia [CPEO]); ...

Overview: Kearns-Sayre syndrome is a rare neuromuscular disorder that primarily affects the eyes. The condition occurs when patients have mutated mitochondria inside their cells.

Ophthalmoparesis Â- Progressive external ophthalmoplegia Â- Palsy (III, IV, VI) Â- Kearns-Sayre syndrome
Other strabismus
Esotropia/Exotropia Â- Hypertropia Â- Heterophoria (Esophoria, Exophoria) Â- Brown's syndrome Â- Duane syndrome ...

Type of dysmyelinating disease, autosomal recessive, onset usually within 2nd year, (?) variant of Pelizaeus-Merzbacher disease, distinguish from Kearns-Sayre syndrome CT findings: microcephaly, basal ganglion calcification, ...

Some disorders historically confused with BBS include Lawrence-Moon syndrome, Kearns-Sayre syndrome, and McKusick-Kaufman syndrome.

An important eye disease called Leber hereditary optic atrophy;
A type of epilepsy called MERRF which stands for Myoclonus Epilepsy with Ragged Red Fibers; and
A neuromuscular disease called the Kearns-Sayre syndrome.

Some of the more common mitochondrial myopathies include Kearns-Sayre syndrome, myoclonus epilepsy with ragged-red fibers, and mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes.

See also: Symptom, Atrophy, Muscle weakness, Weakness, Stroke