Lack of intrinsic factor

Lack of intrinsic factor
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Lack of intrinsic factor
Alternate Names : Intrinsic factor - lack of
Definition ...

A congenital lack of intrinsic factor is thought to be inherited in most cases.
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Congenital Lack of Intrinsic Factor: Symptoms & Signs ...

Lack of Intrinsic Factor
Intrinsic factor is a protein made in the stomach. It helps your body absorb vitamin B12. In some people, an autoimmune response causes a lack of intrinsic factor.

Lack of intrinsic factor
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Lack of intrinsic factor may be due to an autoimmune reaction, in which your immune system mistakenly attacks the stomach cells that produce intrinsic factor.

Pernicious anemia is a type of megaloblastic anemia caused by an inability to absorb Vitamin B-12 due to a lack of intrinsic factor in gastric (stomach) secretions. Intrinsic factor enables the absorption of Vitamin B-12.
malabsorption ...

Most often, the condition is caused by a lack of intrinsic factor, a protein substance that is produced by the stomach and is necessary for the absorption of vitamin B12 in the small intestine.

The type of anemia in which a lack of intrinsic factor occurs is called pernicious anemia.

Pernicious anemia is caused by a lack of intrinsic factor. Intrinsic factor is a protein produced by the stomach that binds to vitamin B12. The combination of vitamin B12 and intrinsic factor is absorbed in the lower part of the small intestine.

Congenital Pernicious Anemia - Congenital Lack of Intrinsic Factor
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Overview, Causes, & Risk Factors, Congenital Lack of Intrinsic Factor, Diseases and Conditions, Blood Disorders, Hemochromatosis, Anemia B12 deficiency Medical Reference Medical Encyclopedia Information
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I have pernicious anaemia due to lack of intrinsic factor resulting from atrophy as I age. I need B12 injections and no additional folate. In fact in my case additional folate is contra-indicated.

A chronic progressive anemia of older adults; thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B-12). [Wordnet].

The Schilling test measures the body's ability to absorb vitamin B12 from the bowel. This will show whether the anaemia is caused by a lack of intrinsic factor.
Blood tests will also confirm if you have any antibodies to intrinsic factor.

where large, immature, nucleated cells (megaloblasts, which are forerunners of red blood cells) circulate in the blood, and do not function as blood cells; it is a disease caused by impaired uptake of vitamin B-12 due to the lack of intrinsic factor ...

Intrinsic factor is essential for the absorption of cobalamin. A lack of intrinsic factor also leads to pernicious anemia, so called because it persists despite iron supplementation.

Abdominal or intestinal surgery that affects intrinsic factor production or absorption
Crohn's disease
Intestinal malabsorption disorders
Fish tape worm
Pernicious anemia, which is caused by a lack of intrinsic factor ...

See also: Intrinsic factor, Deficiency, Anemia, Pernicious anemia, Symptom