Lhermitte-Duclos disease: rare condition in the part of the brain known as the cerebellum (found at the back of the head toward the base of the skull).
Adult Lhermitte-Duclos disease (in which a specific tumor type is found in the cerebellum of the brain)
Skin changes (mainly around the face and mouth)
Trichilemmomas ...
A rare, noncancerous brain tumor called Lhermitte-Duclos disease
Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, ...
protein tyrosine phosphatase: PTEN (Bannayan-Riley-Ruvalcaba syndrome, Lhermitte-Duclos disease, Cowden syndrome, Proteus-like syndrome) Â- MTM1 (X-linked myotubular myopathy) Â- PTPN11 (Noonan syndrome 1, LEOPARD syndrome, Metachondromatosis) ...
Noncancerous breast and thyroid diseases are also common. Other signs and symptoms of Cowden syndrome can include an enlarged head (macrocephaly); a rare, noncancerous brain tumor called Lhermitte-Duclos disease; and intellectual disability.
Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) occurs in the setting of Cowden disease, which is associated with a germline mutation of the gene PTEN/MMAC1 (located on 10q23).
 See also: Cancer, Breast Cancer, Autosomal dominant, Lipoma, Genetics
  
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