Localized diseases are contrasted with disseminated diseases and systemic diseases.
Early localized disease
Rash: solitary erythema migrans (EM, see below), which may be pruritic, painful, or neither ++++
Flulike symptoms: fatigue, headache, fever, stiff neck
Early disseminated disease (may occur in various combinations) ...
Localized disease - Patients with localized disease may be treated with fewer cycles (usually three cycles) of R-CHOP chemotherapy in combination with radiation therapy to the involved area.
Localized disease (stages I and II): Patients with indolent lymphomas rarely present with localized disease, but when they do, regional radiation therapy may offer long-term control. However, relapses may occur > 10 yr after radiation therapy.
STAGE I: localized disease, completely resected without microscopic disease in the resected margins or in regional lymph nodes.
STAGE II: microscopic residual disease, capsular invasion, or microscopic lymph node involvement.
Treatment of localized disease (stages I and II) should consist of “R-CHOP' chemotherapy (3 to 8 cycles) plus radiation to the sites of lymphoma. An alternative to this is “R-CHOP' alone for 4 to 8 cycles.
Lyme disease is medically described in three phases as: (a) Early localized disease with skin inflammation (b) Early disseminated disease with heart and nervous system involvement, ...
The Role of Oxaliplatin for Localized Disease
Oxaliplatin has significant activity when combined with 5-FU-leucovorin in patients with metastatic colorectal cancer.
Hepatocellular carcinoma is potentially curable by surgery, but surgery is the treatment of choice for only a small fraction of patients who have localized disease.
Localized disease never becomes generalized. Amyloid is a waxy pink material made of abnormal proteins that stains with Congo red, and has a typical birefringence with polarization microscopy. Amyloidosis may be primary or secondary.
localized disease [hyaline-vascular type]). Less common sites include the armpit (axilla), pelvis, and pancreas. Usually the growths represent abnormal enlargement of the lymph nodes normally found in these areas (lymphoid hamartoma).
In cases of focal myelitis from injury or disease, recoN ery may take place and the return of power and sensation may occur to such an extent that the patient is able to walk long distances; this happy termination in cases of localized disease or ...
For example, in general a patient with localized disease may have a more favorable prognosis compared to a patient with widespread disease which may be less favorable.
Surgery is limited in treating NHL and is only useful in localized disease or if there is high risk of perforation, obstruction, or hemorrhage.
Source: Medical Disability Advisor
Prognosis ...
About half of AIDS patients with a CD4 count less than 200 who develop TB will have disseminated disease (not localized disease, as in pulmonary TB).
Symptoms
The primary infection usually has no symptoms.
Localized disease that has not spread to the liver --
Cure from the disease is possible only if the tumor is removed before it spreads to the liver. Even if the tumor has spread to the lymph nodes, it does not affect survival.
In children with localized disease, cure rates are as high as 80 percent, and even in metastatic disease, nearly 50 percent cure rates have been reported. The individual patient prognosis for Ewing sarcoma greatly depends on: ...
The cure rate for adrenal malignancies, for instance, is less than 50 percent, even in patients with localized disease that can be removed. Conversely, the prognosis for adrenal adenomas is excellent.
In some cases, patients with indolent NHL may also be able to be followed closely and start treatment only when necessary; this approach is called watchful waiting. In cases of localized disease (stage I-II), ...
 See also: Cancer, Symptom, Aging, Surgery, Prevention
  
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