Lupus anticoagulants
Definition
Lupus anticoagulants are antibodies against phospholipids (substances in the lining of cells) that prevent blood clotting in a test tube.
Lupus anticoagulant.
Anticardiolipin antibodies.
Anti-β glycoprotein I antibodies.
Lupus anticoagulant
This is a special type of antibody that interferes with the normal function of blood vessels. This antibody causes narrowing of the blood vessels and increased likelihood of blood Clotting.
Lupus anticoagulant
To determine cause of recurrent miscarriage . High levels indicate an abnormal factor in the blood that causes clotting complications.
Chromosomal analysis ...
The lupus anticoagulant is suspected if the PTT is prolonged and does not correct immediately upon 1:1 mixing with normal plasma but does return to normal upon the addition of an excessive quantity of phospholipids (done by the hematology laboratory).
Familial lupus anticoagulant
Hughes syndrome
Summary
The antiphospholipid syndrome (APS) is characterized by venous and/or arterial thrombosis, recurrent pregnancy loss and the presence of antiphospholipid antibodies.
The test for the lupus anticoagulant antibody measures the time it takes blood to clot. A longer than normal blood clotting time indicates a higher chance for clotting in the body and, therefore, the presence of lupus anticoagulant.
Immunological factors for pregnancy loss include antiphospholipid antibodies, lupus anticoagulant, antinuclear antibodies, and antithyroid antibodies.
There are two main types of antiphospholipid antibody tests - immunological tests, like the anticardiolipin ELISA (enzyme-linked immunoassay), and coagulation-based tests for the lupus anticoagulant.
About one-third of women with lupus have antiphospholipid antibodies (lupus anticoagulant or anti-cardiolipin antibody) that may cause blood clots and interfere with the proper functioning of the placenta.
If a hypercoagulable state (i.e., the blood forms clots too easily) is suspected, then the lupus anticoagulant, and anticardiolipin antibodies are examined.
This test is positive in about 80% of cases. Another test, confusingly called a lupus anticoagulant test (it's not a test for Lupus) is also used to help confirm the diagnosis and this is positive in about 30-40% of cases.
All pregnant women with systemic lupus erythematosus should be tested for the presence of antiphospholipid antibodies (eg, lupus anticoagulants and anticardiolipin antibodies).
The presence of antiphospholipid antibodies (ACA) and a lupus anticoagulant (LA) is important when evaluating someone who has had recurrent miscarriages or arterial thrombosis.
These antibodies include VDRL/RPR (a syphilis test that can be falsely positive in these patients), lupus anticoagulant, prolonged PTT, and cardiolipin antibody.
FSH-Releasing Hormone, Genes, Structural Fungal, Glomerulus, Kidney, High Risk Women, In-house Mortality, Interferon gamma 1b, Intradermal Tests, Jaagsiekte, Keratoconjunctivitis, Infectious, Legionella pneumophila Infection, Lupus Anticoagulant, ...
It may seem odd that one of the APS antibodies is called lupus anticoagulant. It's called this because the antibody slows clotting in lab tests. However, in the human body, it increases the risk of blood clotting.
For recurrent cases with no obvious explanation, blood testing for clotting factor mutations is performed (Lupus anticoagulant, Factor V Leiden, protein S, protein C, antithrombin III, etc.
Source: Medical Disability Advisor
Treatment ...
Antiphospholipid syndrome is tested for in the laboratory using both liquid phase coagulation assays (lupus anticoagulant) and solid phase ELISA assays (anti-cardiolipin antibodies).
Genetic testing to look for mutations that make you more likely to develop blood clots, including the prothrombin G20210A mutation
Lupus anticoagulant or antiphospholipid antibodies
Protein C and protein S levels ...
that is characterized by excessive clotting of blood and/or certain complications of pregnancy (premature miscarriages, unexplained fetal death, or premature birth) and the presence of antiphospholipid antibodies (cardiolipin or lupus anticoagulant ...
Mutated genes (such as factor V Leiden, factor II).
Decreased amounts of certain proteins (protein C, protein S, and antithrombin III).
Increased levels of other substances (antiphospholipid or lupus anticoagulant).
An immune problem called antiphospholipid syndrome is the cause for recurrent miscarriage in 3 to 15 % of women. The College recommends that women with recurrent miscarriage be tested for lupus anticoagulant and anticardiolipin antibodies ...
(female hormones, estrogens and birth control pills), after surgery (post- operative period, especially hip, knee, and urinary system procedures), pregnancy, phospholipid antibodies in blood (anticardiolipin antibodies, lupus anticoagulant), ...
Lung Surgery (Thoracotomy) for Lung Cancer
Lung transplant for cystic fibrosis
Lupus
Lupus (Systemic Lupus Erythematosus)
Lupus Anticoagulant Syndrome
Lupus erythematosus
Luschka-Magendie Foramina Atresia
Lutz-Splendore-Almeida Disease ...
Immunologic disorder: abnormal immune tests include anti-DNA or anti-Sm (Smith) antibodies, falsely positive blood test for syphilis, anticardiolipin antibodies, lupus anticoagulant, or positive LE prep test ...
Lupus and Pregnancy
Lupus Anticoagulant Syndrome
Lupus erythematosus
Lupus: Criteria for Diagnosis
Lupus: Healthy Eating
Luschka-Magendie Foramina Atresia
Lutz-Splendore-Almeida Disease
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Lupus anticoagulants
Lupus nephritis
Lyme disease
Lyme disease - chronic persistent
Lyme disease - early disseminated
Lyme disease - primary
Lymphadenitis
Lymphangitis
Lymphatic obstruction
Lymphofollicular hyperplasia ...
 See also: Lupus, Symptom, Pregnancy, Surgery, Erythema
  
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